نتایج جستجو برای: synaptonemal complex

تعداد نتایج: 783949  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1971
D von Wettstein

The synaptinemal complex provides a structural basis for four-strand crossing over: prior to chromosome pairing, both sister chromatids of each homologous chromosome participate in the genesis of one lateral component. During precise pairing, the two lateral components are combined into one synaptinemal complex per bivalent.

Journal: :Genes & development 2008
Tomomi Tsubouchi Amy J Macqueen G Shirleen Roeder

Previous studies of synaptonemal complex assembly in budding yeast have suggested that chromosome synapsis initiates at the sites of crossing over. The data presented here, however, indicate that centromeric regions are preferred sites for synapsis initiation. At early times during meiosis in wild type, the Zip1 protein (a major building block of the synaptonemal complex) localizes specifically...

Journal: :Genetics 2004
Eric J White Carrie Cowan W Zacheus Cande David B Kaback

During meiotic prophase a synaptonemal complex (SC) forms between each pair of homologous chromosomes and is believed to be involved in regulating recombination. Studies on SCs usually destroy nuclear architecture, making it impossible to examine the relationship of these structures to the rest of the nucleus. In Saccharomyces cerevisiae the meiosis-specific Zip1 protein is found throughout the...

Journal: :Development 1997
D J Dix J W Allen B W Collins P Poorman-Allen C Mori D R Blizard P R Brown E H Goulding B D Strong E M Eddy

Spermatogenic cells synthesize a unique 70-kDa heat shock protein (HSP70-2) during prophase of meiosis I, and targeted disruption of the Hsp70-2 gene has shown that this protein is required for spermatogenic cell differentiation in adult mice. HSP70-2 is associated with synaptonemal complexes formed between paired homologous chromosomes during meiotic prophase. The present study focuses on the ...

Journal: :The International journal of developmental biology 2000
A D Di Carlo G Travia M De Felici

The synaptonemal complex proteins SCP3 and SCP1 are components of the synaptonemal complex, a meiosis-specific protein structure essential for synapsis of homologous chromosomes. Using polyclonal antibodies raised against SCPs of rat testis, we have studied the expression of these proteins in embryonic germ cells of the mouse embryo using immunohistochemistry and immunoblotting. This investigat...

Journal: :EMBO reports 2016
Rocío Gómez Natalia Felipe-Medina Miguel Ruiz-Torres Inés Berenguer Alberto Viera Sara Pérez José Luis Barbero Elena Llano Tomoyuki Fukuda Manfred Alsheimer Alberto M Pendás Ana Losada José A Suja

The distribution and regulation of the cohesin complexes have been extensively studied during mitosis. However, the dynamics of their different regulators in vertebrate meiosis is largely unknown. In this work, we have analyzed the distribution of the regulatory factor Sororin during male mouse meiosis. Sororin is detected at the central region of the synaptonemal complex during prophase I, in ...

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