We describe here the time course of functional synapse formation and of the development of short-term synaptic plasticity at Aplysia sensorimotor synapses in cell culture, as well as the effects of blocking protein synthesis or postsynaptic receptors on the development of synaptic transmission and plasticity. We find that synaptic responses can be elicited in 50% of sensory neuron-motor neuron ...

bstract—The capacity of activity-dependent synaptic modifiation is essential in processing and storing information, yet ittle is known about how synaptic plasticity alters the input– utput conversion efficiency at the synapses. In the adult ouse hippocampus in vivo, we carefully compared the input– utput relationship, in terms of presynaptic activity levels ersus postsynaptic potentials, before...