BACKGROUND Mycetoma is a neglected, chronic, and deforming infectious disease caused by fungi and actinomycetes. In Mexico, N. brasiliensis is the predominant etiologic agent. Therapeutic alternatives are necessary because the current drug regimens have several disadvantages. Benzothiazinones (BTZ) are a new class of candidate drugs that inhibit decaprenyl-phosphoribose-epimerase (DprE1), an es...

We assessed the clonality of consecutive Escherichia coli isolates during the course of recurrent urinary tract infections (RUTI) in childhood in order to compare clonality with phenotypic antibiotic resistance patterns, the presence of integrons, and the presence of the sul1, sul2, and sul3 genes. Altogether, 78 urinary E. coli isolates from 27 children, who experienced recurrences during a 1-...

Blooms of cyanobacteria are frequent in Brazilian water reservoirs used for drinking water. The warning the presence potential toxin-producing is typically based on time-consuming microscopy, rather than specific molecular detection toxic genes cyanobacteria. In this study, we developed a quantitative PCR assay producing neurotoxin saxitoxin (STX). targets sxtA gene sxt cluster. Potential and d...

Integrating conjugative elements (ICEs) are a class of bacterial mobile genetic elements that disseminate via conjugation and then integrate into the host cell genome. The SXT/R391 family of ICEs consists of more than 30 different elements that all share the same integration site in the host chromosome but often encode distinct properties. These elements contribute to the spread of antibiotic r...

the emergence of multidrug resistant strains of escherichia coli has complicated treatment decision and may lead to treatment failures. from april to november 2001 we prospectively evaluated the prevalence of resistance to trimethoprim-sulfamethoxazole (sxt), gentamicin, cephalothin, ciprofloxacin, and nitrofurantoin in 220 escherichia coli isolates from patients with urinary tract infections i...

ABSTRACT Broad-band spectral studies of type I X-ray bursts can put strong constraints on the physics burst spectra as well their interaction with environment. We present results obtained from broad-band time-resolved spectroscopy 15 thermonuclear detected simultaneously neutron star atoll source 4U 1636?536 using Large Area Proportional Counter (LAXPC) and Soft Telescope (SXT) onboard AstroSat...

(isolate RND19188), even though she had no distinct symptoms of cholera. The source of infection for the woman and child was unclear but was assumed to be related to eating fruit rinsed in tap water while in the city of Vrindavan in India. Maximum-likelihood phylogenetic analysis based on high-quality orthologous single-nucleotide polymorphisms (hqSNPs) among 75 V. cholerae genomes showed that ...

Background: The aim of this study was to investigate the frequency and type of bacteria resistant to chloramphenicol (CHL), erythromycin (E), and sulfamethoxazole (SXT) antibiotics from untreated wastewater effluents to receiving river. Methods: In total, 32 samples were taken from eight sites located in the raw wastewater to the downstream of the receiving Ghotor river in Khoy city. Resistant...