A critical event in ischemia-based cell death is the opening of the mitochondrial permeability transition pore (MPTP). However, the molecular identity of the components of the MPTP remains unknown. Here, we determined that the Bcl-2 family members Bax and Bak, which are central regulators of apoptotic cell death, are also required for mitochondrial pore-dependent necrotic cell death by facilita...

A 70-year-old woman reporting 1 year of non-progressive intermittent solid dysphagia underwent an outpatient endoscopy. Endoscopy was normal, and a 54-French bougie dilator was empirically passed, which encountered moderate resistance in oral cavity. On withdrawal, no blood was noted. The dilator passed freely on the second attempt. Subsequent screening colonoscopy was uneventful. Five hours af...

Oriented strand board (OSB) distributed in Korea was collected, and its mechanical properties were investigated according to the International Organization for Standardization (ISO), Japanese Industrial Standards, Korean Design Standard. Ten types of OSBs including six walls others floors. The thickness swelling, moisture content, density each product satisfied ISO standards. All products showe...

due to the fact that many application processes take place at different temperature, better examining and understanding of swelling properties as a function of temperature is essential for such application. the temperature effect on the swelling properties of commercial polyacrylic acid (paa) hydrogel beads was investigated as a function of time and temperature. gel bead size, swelling equilibr...

The accuracy of joint angle measurement of the hand may be negatively influenced by joint swelling, deformation and other obstacles. We developed an alternative goniometer with clear ergonomic advantages, especially for the measurement of small joints. This new concept of goniometry is described and preliminary results on the reliability of the measurements are presented. The intraclass correla...

introduction: the aim of this study was to assess the effect of low-level laser therapy (lllt) on pain, swelling and maximum mouth opening in patients undergoing third molar surgery. methods: a prospective, randomized double-blind study was undertaken on 44 patients at the dental school, ahvaz jundishapur university of medical sciences, in 2015. a low-level laser was randomly applied on one of ...

Most studies on hydrogel swelling instability have been focused on a constrained boundary condition. In this paper, we studied the mechanical instability of a piece of disc-shaped hydrogel during free swelling. The fast swelling of the gel induces two swelling mismatches; a surface-inner layer mismatch and an annulus-disc mismatch, which lead to the formation of a surface crease pattern and a s...

Caveolae have been implicated in sensing of cell volume perturbations, yet evidence is still limited and findings contradictory. Here, we investigated the possible role of caveolae in cell volume regulation and volume sensitive signaling in an adipocyte system with high (3T3-L1 adipocytes); intermediate (3T3-L1 pre-adipocytes); and low (cholesterol-depleted 3T3-L1 pre-adipocytes) caveolae level...

1. Using cyclic AMP to stimulate perfused tsetse fly Malpighian tubules bathed in SO42- Ringer frequently causes an immediate but transient peak in transtubular potential (Vt), before stabilisation of Vt at an increased value. 2. These transients were investigated by monitoring the associated changes in cable properties and current­voltage (I/V) relationships. Tubules were perfused and bath...