3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors were potent hits against a mouse ependymoma cell line, but their effectiveness against central nervous system tumors will depend on their ability to cross the blood-brain barrier and attain a sufficient exposure at the tumor. Among 3-hydroxy-3-methylglutaryl coenzyme A inhibitors that had activity in vitro, we prioritized simvastatin (S...

To cite: Mahajan K, Asotra S, Negi P, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2015212883 DESCRIPTION A sinus of Valsalva aneurysm (SVA) is an uncommon cardiac anomaly that can be congenital or acquired. SVAs were present in 0.09% of cadavers in a large autopsy series and ranged between 0.14–0.23% in a Western surgical series. A congenital SVA is usu...

OBJECTIVE To evaluate the value and improve the diagnostic accuracy of echocardiography in the diagnosis of a sinus of Valsalva aneurysm (SVA) with rare pathological patterns. METHODS Echocardiographic features and surgical findings from 270 Chinese patients with SVA treated in the last 18 years (1995-2013) at the Union Hospital were compared retrospectively; 22 of 270 cases had rare patterns...

Comparison of conjunctival impression cytology (CIC) with ocular signs and vitamin A levels was done based upon a national nutrition survey involving 427 randomly selected subjects aged 6 months to 6 years. Medical nutritionists looked for ocular signs and performed conjunctival impressions. Imprints were submitted to the Institute of Ophthalmology, University of the Philippines-Philippines Gen...

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors were potent hits against a mouse ependymoma cell line, but their effectiveness against central nervous system tumors will depend on their ability to cross the blood–brain barrier and attain a sufficient exposure at the tumor. Among 3-hydroxy-3-methylglutaryl coenzyme A inhibitors that had activity in vitro, we prioritized simvastatin (S...

It has unambiguously been shown that genetic, environmental, demographic, and technical factors may have substantial effects on gene expression levels. In addition to the measured variable(s) of interest, there will tend to be sources of signal due to factors that are unknown, unmeasured, or too complicated to capture through simple models. We show that failing to incorporate these sources of h...

ness should be run to maximize the return on shareholders’ investment, and shareholder value analysis (SVA) is fast becoming a new standard for judging managerial action. In this changing scenario, in which short-term accounting profits are giving way to SVA, it is advisable that all investments made by managers be viewed in the context of shareholder returns. Thus, every investment, be it in t...

PATIENT Male, 23 FINAL DIAGNOSIS: Sinus of valsalva aneurysm (SVA) Symptoms: Chest pain • low O2 saturation • short of breath MEDICATION - Clinical Procedure: - Specialty: Cardiology. OBJECTIVE Rare disease. BACKGROUND Sinus of valsalva aneurysm (SVA) is a rare cardiac anomaly. It may be congenital or acquired; a coexisting cardiac lesion might be present. Rupture of the aneurysm, where i...

UNLABELLED SummaryWe present quite a rare case of extracardiac unruptured right sinus of valsalva aneurysm (SVA) complicated with atherothrombosis in a young adult man. A 35-year-old male with a giant unruptured SVA arising from the right coronary sinus (RCS) with extracardiac protrusion was diagnosed by echocardiography. Contrast-enhanced computed tomography (CT) revealed a huge calcified aneu...

cardiac anomaly (1). SVA most commonly originates in the right coronary sinus of Valsalva (75-90%), the noncoronary sinus (10-25%), and rarely, in the left sinus (1, 2). Unruptured SVA usually remains asymptomatic, but it can sometimes cause cardiac arrhythmia, myocardial ischemia, or systemic embolic events (1-3). Multidetector computed tomography (MDCT) is a useful modality for examining the ...