Unbiased identification of susceptibility genes might provide new insights into pathogenic mechanisms that govern complex inflammatory diseases such as multiple sclerosis. In this study we fine mapped Eae18a, a region on rat chromosome 10 that regulates experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. We utilized two independent approaches: (1) in silico ...

Diffusion MRI has become an invaluable tool for studying white matter microstructure and brain connectivity. The emergence of quantitative susceptibility mapping and susceptibility tensor imaging (STI) has provided another unique tool for assessing the structure of white matter. In the highly ordered white matter structure, diffusion MRI measures hindered water mobility induced by various tissu...

In the field of wildfire risk management the so-called burn probability maps (BPMs) are increasingly used with the aim of estimating the probability of each point of a landscape to be burned under certain environmental conditions. Such BPMs are usually computed through the explicit simulation of thousands of fires using fast and accurate models. However, even adopting the most optimized algorit...

The goal of this study was to identify pig chromosomal regions associated with susceptibility to salmonellosis. Genomic DNA from pig reference populations with differences in susceptibility to Salmonella enterica serovar Choleraesuis as quantified by spleen and liver bacterial colonization at day 7 post-infection (dpi; Van Diemen et al. 2002) was used. These samples belonged to the offspring of...

We present a suite of extensions for ARCVIEW GISTM (ESRI) that allows to map the spatial distribution of first-order mechanical slope-properties in hard rock terrain, e.g. for large slope areas like water reservoir slopes. Besides digital elevation data, this expert-system includes regional continuous grid-based data on geological structures that might act as potential sliding or cutoff planes ...

Quantitative Susceptibility Mapping (QSM) aims to estimate the tissue susceptibility distribution that gives rise to subtle changes in the main magnetic field, which are captured by the image phase in a gradient echo (GRE) experiment. The underlying susceptibility distribution is related to the acquired tissue phase through an ill-posed linear system. To facilitate its inversion, spatial regula...

INTRODUCTION Susceptibility weighted imaging at ultrahigh magnetic fields (B0≥7T) has become a new forefront of research, triggered by the anticipated increase in signal-to-noise ratio (SNR), higher spatial resolution, and improved contrast mechanisms. Employing these advantages superb anatomical contrast has already been demonstrated for both magnitude [1,2] and phase images [2-4]. These phase...

The inverse problem of QSM is to recover the susceptibility distribution of the human body from the measured local field that is expressed by the convolution of the susceptibility distribution with the magnetic field generated by a unit dipole. However, it is ill-posed due to the presence of zeros at a cone in the Fourier representation of the unit dipole kernel. Due to this ill-posedness, the ...

BACKGROUND Quantitative susceptibility mapping (QSM) and R2* relaxation rate mapping have demonstrated increased iron deposition in the substantia nigra of patients with idiopathic Parkinson's disease (PD). However, the findings in other subcortical deep gray matter nuclei are converse and the sensitivity of QSM and R2* for morphological changes and their relation to clinical measures of diseas...

This Report is presented to Geological Survey of Ireland in respect of the Landslide Susceptibility Mapping Project and may not be used or relied on by any other person or by the client in relation to any other matters not covered specifically by the scope of this Report. Notwithstanding anything to the contrary contained in the report, Mouchel is obliged to exercise reasonable skill, care and ...