Background Susac Syndrome (SS) is a rare autoimmune endotheliopathy that affects the brain, retina, and inner ear, characterized by clinical triad of encephalopathy, branch retinal artery occlusion (BRAO), sensorineural hearing loss (SNHL) [1] . Brain MRI, fluorescein angiogram (FA), audiometry help to establish diagnosis [2] The presentation SS often variable leading delay in diagnosis. Object...

CD8+ lymphocytes are adaptive immunity cells with the particular function to directly kill target cell following antigen recognition in context of MHC class I. In addition, T may release pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ), a plethora other cytokines chemoattractants modulating immune inflammatory responses. A role for has been suggested ...

Purpose The purpose of this study was to perform a genome-wide scan for polymorphisms associated with risk of vision loss from radiation complications in patients treated with proton beam irradiation for choroidal melanoma. Methods We identified a cohort of 126 patients at high risk of radiation complications due to tumor location within 2 disc diameters of the optic nerve and/or fovea who pr...

Susac's syndrome (SS) is a disease of the microvasculature of the retina, brain, and inner ear. We describe a patient with unusual manifestations of SS with possible involvement of the brainstem, cardiac arrhythmia, and MRI findings lacking the characteristic lesions found in Susac's syndrome.