The property of synergy and its detection are discussed. A response surface is said to possess synergy if it is monotone in each argument and its level curves are convex. Detecting this property is particularly useful in the study of combination drug therapies where the goal is enhanced response or diminished side effect. One way to detect synergy is to fit a surface with linear level curves un...

Custom microsystems are expensive, innexible, and unsuitable for high-volume production. We address this problem by leveraging hardware/software co-design principles to design reconngurable composite microsystems. We partition the system design parameters into nonre-conngurable and reconngurable categories. In this way, the operational exibility is enhanced and the microsys-tems are designed fo...

Received: April 11, 2016 Revised: August 5, 2016 Accepted: August 9, 2016 Abstract: Background: Recent interest in the health promoting potential of anthocyanins points to the need for robust and reliable analytical methods. It is essential to know that the health promoting chemicals are present in juices and other products processed from whole fruit. Many different methods have been published ...

In this paper we analyze the possibilities of intergenerational risk sharing in a generational DB pension fund. Each generation is subject to discretionary investment, indexation and contribution policies, thereby losing intergenerational diversification gains. Intergenerational risk sharing is repaired by introducing contingent claims on the generational surplus or deficit. We find that in som...

Computer-generated designs in the cube are described which have the minimal (or larger) number of runs for a full quadratic response-surface design. Examples of 2-factor designs are included with 6 to 20 runs, 3-factor designs with 10 to 20 runs, 4-factor designs with 15 to 20 runs, 5-factor designs with 21 to 25 runs, 6-factor designs with 28 to 31 runs, and 7-factor designs with 36 and 39 run...

The attitudes and response of “policy receivers” should be taken into more consideration when governments make regulation policy. This paper discusses the public’s degree of understanding, support willingness, implement willingness, and influence willingness to the policy, as well as the mutually responding scenario by using the quadratic response surface regression analysis from the perspectiv...

Received 02 Sept 2016 Revised 10 Oct 2016 Accepted 07 Nov 2016 Available online 03 Dec 2016

Norfarina Muhamad Nor, Rosfarizan Mohamad*, Hooi Ling Foo and Raha Abdul Rahim Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, University of Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia Laboratory of Industrial Biotechnology, Institute of Bioscience, University of Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia Depa...

A spectrofluorometric method is described for the determination of germanium(IV) based on its complexation reaction with quercetin in presence of Brij-35. The fluorescence is monitored at 552 nm with excitation at 432 nm. The pH, quercetin and Brij-35 concentrations were optimized simultaneously using the response surface methodology from sequential experimental three-variable Doehlert designs....

This paper investigates the use of Kriging in random simulation when the simulation output variances are not constant. Kriging gives a response surface or metamodel that can be used for interpolation. Because Ordinary Kriging assumes constant variances, this paper also applies Detrended Kriging to estimate a non-constant signal function, and then standardizes the residual noise through the hete...