It is now clear that functionally specialized regulatory T (Treg) cells exist as part of the normal immune repertoire, preventing the development of pathogenic responses to both selfand intestinal antigens. Here, we report that the Treg cells that control intestinal inflammation express the same phenotype (CD25 1 CD45RB low CD4 1 ) as those that control autoimmunity. Previous studies have faile...

The tumor microenvironment is a complex milieu of tumor and host cells. Host cells can include tumor-reactive T cells capable of killing tumor cells. However, more frequently tumor and host components interact to generate a highly immune suppressive environment that frustrates T cell cytotoxicity and promotes tumor progression through a variety of immune and non-immune mechanisms. Myeloid-deriv...