Mammalian genes frequently present allelic variants that differ in their expression levels and that, in the case of tumor suppressor genes, can be of relevance for cancer susceptibility and aging. We report here the characterization of a novel mouse model with increased activity for the Ink4a and Arf tumor suppressors. We have generated a "super Ink4a/Arf" mouse strain carrying a transgenic cop...

Metazoan genes are embedded in a rich milieu of regulatory information that often includes multiple enhancers possessing overlapping activities. In this study, we employ quantitative live imaging methods to assess the function of pairs of primary and shadow enhancers in the regulation of key patterning genes-knirps, hunchback, and snail-in developing Drosophila embryos. The knirps enhancers exh...

The application of logarithmic transformations to speckle images is sometimes desirable in converting the speckle noise distribution into an additive, constant-variance noise distribution. The optical transmission properties of some bacteriorhodopsin films are well suited to implement such a transformation optically in a parallel fashion. I present experimental results of the optical conversion...

Feature transformation is an important process following feature extraction for improving classification performance. It has been frequently addressed in the kernel-based framework utilizing non-linear kernel functions, and the additive kernel equipped with explicit feature mapping works as efficient and effective (non-linear) feature transformation. The kernel functions, however, are defined i...

TTC’2015 is the 8th Transformation Tool Contest for users and developers of transformation tools. In this paper, we present the use of Spoon, an open-source library to transform and analyze Java source code for the code refactoring track of TTC’2015. We use Spoon to implement pull-up-method and create super-class refactorings. The implementation uses an unmodified revision of Spoon and is done ...

We present a supersymmetric and κ-symmetric D-string action on AdS5 × S5 in supercoset construction. As in the previous work of the super D-string action in the flat background, the super D-string action on AdS5 × S5 can be transformed to a form of the IIB Green-Schwarz superstring action with the SL(2, Z) covariant tension on AdS5 × S5 through a duality transformation. In order to understand a...

We propose a novel, projection based way to incorporate the conditional information into the discriminator of GANs that respects the role of the conditional information in the underlining probabilistic model. This approach is in contrast with most frameworks of conditional GANs used in application today, which use the conditional information by concatenating the (embedded) conditional vector to...

A q-deformed free spinning relativistic particle is discussed in the framework of the Lagrangian formalism. Three equivalent Lagrangians are obtained for this system which are endowed with q-deformed local (super)gauge symmetries and reparametrization invariance. It is demonstrated that these symmetries are on-shell equivalent only for q = ±1 under particular identification of the transformatio...

We prove a full completeness theorem for multiplicative-additive linear logic (i.e. MALL) using a double gluing construction applied to Ehrhard’s ∗-autonomous category of hypercoherences. This is the first non-game-theoretic full completeness theorem for this fragment. Our main result is that every dinatural transformation between definable functors arises from the denotation of a cut-free MALL...

Unlike technologies that are applicable in a few specific industries, information technologies have a wide range of applicability across almost all industries. The fundamental principles of good IT management are also applicable in many industries. Thus, firms whose business units operate in different industries have an opportunity to exploit cross-unit IT synergies by applying their IT resourc...