نتایج جستجو برای: sulphonylureas

تعداد نتایج: 259  

Journal: :Journal of neurophysiology 1998
E Guatteo M Federici A Siniscalchi T Knöpfel N B Mercuri G Bernardi

The effects of brief (2-4 min) hypoxia on presumed dopaminergic "principal" neurons of the rat ventral mesencephalon were investigated by using either intracellular or whole cell patch-clamp recordings in in vitro conditions. Under single-electrode voltage clamp, with sharp microelectrode (Vh -60 mV), a brief hypoxia caused an outward current (hypoOUT) of 110.2 +/- 15.2 (SE) pA (n = 18), which ...

2010
Hasniza Z. HURI Amy T.-L. WEI Rokiah PENDEK Che Z. SULAIMAN Riyanto T. WIDODO

INTRODUCTION In Malaysia, majority of diabetes mellitus cases are type 2 diabetes mellitus (T2DM). This is a direct extension from the fact that in 1997, 97 % of all cases of diabetes mellitus are T2DM 1. The oral drugs used for the treatment of T2DM are known as oral hypoglycemic agents (OHAs). The most frequently prescribed OHAs are SUs. In the Malaysian Statistics on Medicine 2004, SUs makes...

Journal: :Biochemical Society transactions 2015
Heidi de Wet Peter Proks

“IC is the current in drug free solution obtained by averaging the current before and after application, IC50 is the drug concentration at which the inhibition is half maximal, h is the Hill coefficient, L is a scaling factor reflecting the difference between channel activity in control and MgATPcontaining solution (L = 1 in the absence of the nt) and a is the fraction of KATP current remaining...

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