Single crystals of sulphamethoxazole were X-irradiated at 273 K. ESR and ENDOR spectra were obtained at 100 K. The free radicals stable at room temperature are formally formed by abstraction of a hydrogen atom from the methyl group of the molecule. The unpaired electron is delocalized in the isoxazole ring. The assignment is supported by comparisons of spin densities obtained experimentally and...

A case of nocardiosis in a post-renal transplant patient is being reported for the first time from Eastern India. The patient had multiple abscesses on the right thigh and chest. Direct examination of the aspirated pus by Gram stain and modified Ziehl Neelsen stain revealed gram-positive beaded, partially acid-fast, branching filaments. Culture of the pus yielded Nocardia asteroides. The patien...

INTRODUCTION Whipple's disease is a rare systemic infectious disorder caused by Tropheryma whipplei. CASE PRESENTATION We report a 68-year-old male with Whipple's disease of the central nervous system following long-term antibiotic therapy and many years after the initial clinical onset. CONCLUSION The combination of trimethoprim and sulphamethoxazole does not prevent or cure involvement of...

Four chronic typhoid carriers from the Aberdeen typhoid outbreak of 1964 were treated with trimethoprim-sulphamethoxazole. The male carrier remained clear of infection following treatment but the three female carriers, all with gall bladder abnormalities, remained excretors. A convalescent typhoid excretor also remained clear of infection after treatment as well as two other salmonella carriers...

A detailed appraisal of the British seafarer and his way of life is described and the prevailing management of sexually transmitted disease in the seafarer is outlined. It is shown that the available statistics on the incidence of sexually transmitted disease among seafarers are inadequate. Management at sea and ashore remains generally unsatisfactory. Suggestions are made to improve the manage...

The case is reported of a patient who developed a vertebral osteomyelitis caused by Enterobacter cloacae. The organism was isolated in cultures of blood and vertebral puncture biopsy samples. The patient was satisfactorily treated with trimethroprim and sulphamethoxazole. Enterobacter cloacae, a Gram negative organism, has been confirmed as the cause of bacteremia in patients with burns, urinar...

An outbreak of infection by Pseudomonas cepacia, previously reported (Speller, Stephens, and Viant, 197i), arising from contaminated aqueous chlorhexidine solutions, included two cases of endocarditis affecting recently-inserted prosthetic mitral valves. The bacterium was resistant to most chemotherapeutic agents, but treatment with a combination of co-trimoxazole (trimethoprim plus sulphametho...

We evaluated 582 Haemophilus influenzae isolates from patients between January 2000 and December 2004. Overall, 433 isolates were obtained from sputum and bronchial washings, 124 isolates were from pus, 19 isolates were from blood and 6 isolates form cerebrospinal fluid. H. influenzae was sensitive to amoxicillin/clavulanate, ampicillin/sulbactam, gentamicin, cefuroxime, ceftriaxone, cefotaxime...

Twelve out of 14 strains of Pseudomonas pseudomallei were inhibited in vitro by a combination of trimethoprim 1 mug per ml and sulphamethoxazole 20 mug per ml or by lower concentrations. Of the remaining strains, one was marginally more resistant and one was distinctly so. In tests utilizing two of the sensitive strains, inhibitory concentrations of the individual drugs exerted a bactericidal e...