The airway surface liquid (ASL) is the thin layer of fluid coating the luminal surface of airway epithelial cells at an air interface. Its composition and osmolality are thought to be important in normal airway physiology and in airway diseases such as asthma and cystic fibrosis. The determinants of ASL osmolality include epithelial cell solute and water transport properties, evaporative water ...

The biocompatibility and biodegradability of magnesium (Mg), along with its lightness, make magnesium-based materials promising for use in the biomedical industry. In this work, ternary Mg–Zn–Ca alloys were manufactured applications using mechanical alloying (MA). objective work was to study effect milling time on produced Mg65–Zn30–Ca5 Mg70–Zn25–Ca5 (percentages by weight), degradation synthet...

We report that self-assembled monolayers of colloidal silver nanoparticles can increase the intensity of the surface plasmon-coupled emission (SPCE) signal from sulforhodamine 101 (S101). The S101 was spin coated on a glass slide coated with a layer of continuous silver, and a silica layer upon which the nanoparticle layer was self-assembled. Of the various colloid sizes studied, the 40 nm coll...

In our endeavor towards the development of potent anticancer agents, two different sets of biphenylurea-indolinone conjugates, 5a-s and 8a,b were synthesized. The in vitro cytotoxicity of the synthesized compounds was examined in two human cancer cell lines, namely MCF-7 breast cancer and PC-3 prostate cancer cells using the sulforhodamine B (SRB) colorimetric assay. In particular, the MCF-7 ca...

Chalcones have been shown to exhibit anti-cancer properties by targeting multiple molecular pathways. It was, therefore, of interest to investigate flavokawain C (FKC), a naturally occurring chalcone, which can be isolated from Kava (Piper methysticum Forst) root extract. The aim of this study was to investigate the inhibitory effect of FKC on the growth of HT-29 cells and its underlying mechan...

euphorbia wallichii a perennial herb growing mainly in himalayas has been widely used in folk medicines for its medicinal properties. in the present study, the crude methanolic root extract (cme) and its fractions; n-hexane fraction (nhf), n-butanol fraction (nbf), chloroform fraction (chf), ethyl acetate fraction (eaf) and aqueous fraction (aqf) of this plant specie were investigated for antio...

PLGA microparticles loaded with three different fluorescent model drugs, fluorescein sodium (hydrophilic), sulforhodamine (amphoteric), and boron-dipyrromethene (BODIPY(®) 493/503, lipophilic), were prepared by the solvent evaporation technique. Due to varying hydrophilicity, the diameters of the microparticles ranged between 4.1 and 4.7 μm. According to fluorimetric analysis, the loading varie...

Piper nigrum is broadly acted as a herbal medicine and anticancer activity well. Previously, we reported that extract caused induction of breast cancer cells death reduction cell migration in vitro study. In this present study, need to explore the effects on human HeLa cervical underlying mechanism. Sulforhodamine B, colony formation, cycle arrest, acridine orange/ethidium bromide staining was ...

CONTEXT Scyphiphora hydrophyllacea is a shrub mangrove plant of the family Rubiaceae and not yet been studied for anti-hepatocarcinogenic effects. OBJECTIVES We investigated possible in vitro anti-hepatocarcinogenic and antioxidant properties of S. hydrophyllacea. MATERIALS AND METHODS Dried leaves of S. hydrophyllacea were sequentially extracted into hexane, chloroform, ethyl acetate, and ...