INTRODUCTION Our various previous findings have shown the suitability of norfloxacin in the treatment of bacterial infections and burn wounds in alone as well as in combination with Curcuma longa in various topical (ointments, gels, and creams) and transdermal drug delivery systems. AIMS AND METHODS Keeping these facts in consideration, we have made an another attempt to prepare semisolid for...

OBJECTIVE In an attempt for better treatment of bacterial infections and burn wounds, plaster formulations containing different concentrations of norfloxacin were prepared using polymers like polyvinylpyrrolidone and polyvinyl alcohol and evaluated for physicochemical parameters, in vitro drug release, antimicrobial activity, and burn wound healing properties. The prepared formulations were com...

OBJECTIVES The aim of this study was to evaluate the effects of Malva sylvestris aqueous extract on cutaneous wound healing in BALB/c mice. MATERIALS AND METHODS Twenty seven male BALB/c mice (2.5 months of age) were used. A cut wound (superficial fascia depth) was made locally. The mice were then divided into three groups: the first, second and third groups received topical administration of...

was shorter than that of the controls (7.1 days) and the total amount of saline required was less in the sulphadiazine-treated cases than in the controls. Chu, Huang, Chang arid Kao (1946) report the treatment of 25 cases of cholera with sulphadiazine and compare the result with that of 29 cases not treated with sulphadiazine and claim efficiency for sulphadiazine on clinical data. The results ...

The antimicrobial activity of silver sulphadiazine has been determined agonist 409 strains from 12 different genera. MICs were usually in the range 16-64 micrograms/ml. Multi-resistant species, such as methicillin-resistant Staphylococcus aureus and Acinetobacter spp., were uniformly sensitive. MICs always exceeded the reported aqueous solubility of silver sulphadiazine. No resistant strains we...

Although certain members of the sulfonamide group of drugs have been used in the treatment of the complications of whooping cough,4' 5' 7, 8, 9, 12, 13 but little attention has been given to their effect on the specific organism, Hemophilus pertwssis. Previous work"' has failed to show a favorable influence of sulfanilamide and sulfapyridine on the course of experimental pertussis in the mouse....

Silver nanoparticles supported on nanoscale silicate platelets (AgNP/NSP) possess interesting properties, including a large surface area and high biocide effectiveness. The nanohybrid of AgNP/NSP at a weight ratio 7/93 contains 5-nm Ag particles supported on the surface of platelets with dimensions of approximately 80×80×1 nm(3). The nanohybrid expresses a trend of lower cytotoxicity at the con...

Concentrations of 20 mug of sulfadiazine or 30 mug of d-cycloserine/ml were found to be suitable for testing the differential susceptibility of Chlamydia trachomatis and C. psittaci to these drugs in cell cultures.

Kinetic data for the solid-state reaction of sulfadiazine and acetylsalicylic acid are presented. A compaction method was used to observe the influence of applied pressure, particle size, and temperature on the reaction rate.

Proton transfer to the sulfa drug sulfadiazine [systematic name: 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide] gave eight salt forms. These are the monohydrate and methanol hemisolvate forms of the chloride (2-{[(4-azaniumylphenyl)sulfonyl]azanidyl}pyrimidin-1-ium chloride monohydrate, C(10)H(11)N(4)O(2)S(+) · Cl(-) · H2O, (I), and 2-{[(4-azaniumylphenyl)sulfonyl]azanidyl}pyrimidin-1-ium chlori...