Objective: The present work is based on the above pyrazoline derivative form heterocyclic substituted chalcone. Methods: elemental analysis, IR, 1H and 13C NMR mass spectrum analyses were used to characterise structures of obtained compounds. Results: scheme-1 scheme-2 describe synthesis chalcone (thiophene-fluorenyl derivative) pyrazolines respectively. Chalcone has been synthesized from 2-Ace...

Several new and know 6-(4-substituted phenyl)-4-(4-substituted phenyl)-2-phenyl-6H-1,3-thiazine (or selenazine) (Z4B7, Z4D5, Z4B7' Z4D5') were prepared by the 1,4-Michael addition reaction of chalcone derivatives with thiobenzamide or phenylselenocarboxamide in basic medium (where chalcones was formed Claisen-Schimidt condensation aromatic aldehydes 4-substituted acetophenone presence sodium hy...

Objective: Cancer is one of the major causes of death worldwide irrespective of the sex. The aim of the study was to design, synthesize, and identification of novel anti-proliferative agents that can potently target cancer. Methods: We are reporting the synthesis of the new series of N-substituted 2-(2-butyl-4-chloro-1H-imidazole-5-yl)-1H-benzo[d]imidazole derivatives and evaluated for their an...

A series of new 2-butyl-1H-benzo[4,5]imidazo[1,2-a]imidazo[4,5-e]pyridine-5-carbonitrile derivatives were synthesized by the self cyclisation of (E)-2-(1H-benzo[d]imidazol-2-yl)-3-(2-butyl4-chloro-1H-imidazol-5-yl)acrylonitrile in the presence of piperidine as catalyst, which in turn were prepared by the condensation of substituted N-alkyl 2-butyl-4-chloro-1H-imidazole-5-carbaldehydes with 2-cy...

the present study aimed to use a method for the synthesis of some 3, 4-dihydropyrimidin-2-(1h) - ones/thiones. the study tried to answer the question whether this reaction can be performed without solvent and with new catalyst or not. to find answer to the question, we described a novel protocol for the efficient synthesis of 3, 4-dihydropyrimidin-2-(1h)-one derivatives using aromatic aldehyde,...

Four pyrazole compounds, 3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbaldehyde (1), 5-(4-bromophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbaldehyde (2), 1-[5-(4-chlorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone (3) and 1-[3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]propan-1-one (4), have been prepared by condensing chalcones with hydrazin...

Two glycosphingolipids, GSL-1 and GSL-3, were isolated from Sphingomonas capsulata and studied by methylation analysis, laser desorption mass spectrometry, and 1H and 13C NMR spectroscopy, including two-dimensional 1H,1H COSY and heteronuclear 13C,1H COSY experiments. GSL-1 and GSL-3 differ in their carbohydrate part, their structures being alpha-D-GlcpA-(1-->1)-Cer and alpha-D-Galp-(1-->6)-alp...

PURPOSE To synthesize a new series of 5-substituted-3-methylsulfanyl-1H-pyrazole-4-carboxylic acid ethyl esters for their analgesic and anti-inflammatory activity. METHODS The title compound synthesized by reacting the amino group of 5-amino-3-methylsulfanyl-1H-pyrazole-4-carboxylic acid ethyl ester with acid anhydrides, acid chlorides and phenyl dithiocarbamates. The synthesized compounds we...