AIMS To characterize the natural history of methamphetamine withdrawal during the first 3 weeks of abstinence. DESIGN Cross-sectional study with comparison group. Setting A substance use treatment facility in Chiang Mai Province, Thailand. PARTICIPANTS The sample comprised 21 in-patients undergoing treatment for methamphetamine dependence. Nine age- and sex-matched non-dependent individuals...

BACKGROUND Guidelines exist for the management of alcohol withdrawal syndrome (AWS) but few have been assessed as to their suitability for general hospitals. The Glasgow Assessment and Management guideline for alcohol has been specifically developed for use in this context. AIM To determine if this alcohol assessment guideline aids the management of AWS in general hospitals. DESIGN The four...

Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. On the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. Therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in dr...

BACKGROUND Tramadol is a centrally acting opioid analgesic used to treat moderate to sever pain. It has more advantage and less opioid adverse effects than conventional opioid analgesia. CASE REPORT This article reports a patient with tramadol dependency that had psychosis after tramadol withdrawal. CONCLUSION By the increase of tramadol usage for relief of chronic pain, tramadol abuse and ...

introduction: morphine withdrawal syndrome is mediated via several central and peripheral neurological pathways. in the present study we investigated the role of n-methyl-d aspartic acid (nmda) glutamate receptor on naloxone-induced withdrawal syndrome in morphine-conditioned mice. materials and methods: we designed two separate experiments. in experiment one, 30 male nmri mice were divided int...

264 The fact that alcohol is an addictive drug has been known to man for millennia. Alcohol abuse/dependence is the most common substance-related disorder. A drug can be defined as a substance that produces tolerance (increasingly large amounts are needed to produce the same effect) and withdrawal (psychological and physical distress develop after substance use ceases). The addicted person suff...

Recent studies have shown that NMDA receptors are involved in the tolerance and dependence to opioids. In addition, it has been reported that ketamine, dextromethorphan and amantadine have antagonistic activity at NMDA receptors. Therefore, this study was conducted to clarify the effect of these drugs on morphine withdrawal syndrome. Morphine dependence was induced by increasing doses of morphi...

BACKGROUND In this Part II psychiatric disorders coexisting with organic diseases are discussed. "Comorbidity phenomenon" defines the not univocal interrelation between medical illnesses and psychiatric disorders, each other negatively influencing morbidity and mortality. Most severe psychiatric disorders, such as schizophrenia, bipolar disorder and depression, show increased prevalence of card...

Increasing tendency to drug use is a major social problem, Treatment attempts, regardless of the motivation, are not complete. The study aimed to investigate the relationship between treatment motivation, substance use, craving, withdrawal symptoms and health locus of control in addicted patients. Research population this study included all male and female patients referring to the addiction tr...