Abstract Background Sublingual buprenorphine is an atypical opioid that potentially has a wider safety profile than conventional opioids. However, there paucity of literature concerning its role in acute postoperative pain. Aim To describe the use sublingual including efficacy and for management pain at comprehensive cancer centre. Method A retrospective study analgesia after surgery between 1 ...

BACKGROUND Many drug users present to primary care requesting detoxification from illicit opiates. There are a number of detoxification agents but no recommended drug of choice. The purpose of this study is to compare buprenorphine with dihydrocodeine for detoxification from illicit opiates in primary care. METHODS Open label randomised controlled trial in NHS Primary Care (General Practices)...

Opioid use in pregnant women has increased over the last decade. Following birth, infants with in utero exposure demonstrate signs and symptoms of withdrawal known as the neonatal abstinence syndrome (NAS). Infants express a spectrum of disease, with most requiring the administration of pharmacologic therapy to ensure proper growth and development. Treatment often involves prolonged hospitaliza...

OBJECTIVES This study compared 24-, 48-, 72-, and 96-hour buprenorphine dosing regimens in opioid-dependent outpatients. METHODS Fourteen subjects received buprenorphine in a double-blind, placebo-controlled crossover trial. Daily sublingual maintenance doses were 4 mg/70 kg (n = 5) and 8 mg/70 kg (n = 9). After a stabilization period of maintenance administration, subjects received, in a ran...