نتایج جستجو برای: subdomains of her2
تعداد نتایج: 21166792 فیلتر نتایج به سال:
The polyphenol silybin has anti-oxidant and anti-cancer properties. The poor bioavailability of some polyphenols (flavonoids, and terpenoids) can be improved by binding them to phosphatidylcholine (phytosome technology). Many studies have focused on the most common phytosome, silybin-phosphatidylcholine, particularly for its hepatoprotective effects. However, in recent years, studies have also ...
ABSTRACT HER2-targeted therapy with the HER2 monoclonal antibody trastuzumab has achieved impressive outcomes in first-line settings of patients advanced gastric and gastroesophageal junction (GEJ) adenocarcinoma overexpressing HER2. However, considering that a substantial proportion those eventually relapses, as well relatively limited performance agents second-line settings, deeper understand...
Designed ankyrin repeat proteins (DARPins) are a novel class of binding molecules, which can be selected to recognize specifically a wide variety of target proteins. DARPins were previously selected against human epidermal growth factor receptor 2 (Her2) with low nanomolar affinities. We describe here their affinity maturation by error-prone PCR and ribosome display yielding clones with zero to...
مقدمه مننژیوم شایعترین تومور داخل جمجمهای اولیه با فراوانی قریب 30% میباشد. سیستم تقسیم بندی WHO 2007 مننژیوم را به سه درجه تقسیم کرده است. عود زودهنگام شایعترین سناریوی شکست درمان جراحی مننژیوم است.HER2 یک پروتئین غشایی با فعالیت تیروزین کینازی میباشد که در سرطانهای مختلف از جمله آدنوکارسینوم پستان افزایش بیان آن مشاهده شده است و هدف درمان دارویی با Herceptin میباشد.P53 یک ژن سرکوب کنند...
Background: Elucidating the clinical features of metastatic breast cancer (MBC) patients with an exceptionally favorable prognosis may offer insights to improve survival more typical patients. Methods: We collected comprehensive real-world data on clinicopathologic characteristics, treatments, and outcomes 110 consecutive MBC who survived for over ten years from warehouse Samsung Medical Center...
In domain decomposition algorithms with more than a few subdomains, there is a crucial need for a mechanism to provide for global communication of information at each step of the iterative process. The convergence rate will decay rapidly with an increasing number of subdomains if communication is only between neighboring subdomains. For iterative substructuring algorithms (those domain decompos...
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A bound is obtained for the condition number of a two-level overlapping Schwarz algorithm for problems posed in H(curl) in 2D, where the subdomains are only assumed to be uniform in the sense of Peter Jones. The coarse space is based on energy minimization and its dimension equals the number of subdomain edges. Local direct solvers over overlapping subdomains are also used. The bound is indepen...
زمینه و هدف: وجود تکثیر ژن her2 جهت پیش بینی وضعیت و انتخاب درمان، در بیماران مبتلا به سرطان پستان، تعیین کننده است. آنالیز تکثیر ژن her-2 با استفاده از روش mlpa که روش جدید در بررسی های بالینی می باشد ، انجام گردید. مواد و روش کار: در این مطالعه توصیفی، تعداد 60 بیمار مبتلا به سرطان سینه را که در بیمارستان افضلی پور کرمان، جراحی شدند، از نظر مضاعف شدگی her2 به روش mlpa مورد مطالعه قرار گرفتن...
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