Previously diagnosed diabetes mellitus, newly diagnosed diabetes mellitus, and impaired glucose tolerance are important determinants of the risk of clinical cardiovascular disease (CVD). We have evaluated the relation of patients with subclinical CVD, diabetes, and impaired glucose tolerance and “normal” subjects and the risk of clinical CVD in the Cardiovascular Health Study. Diabetes (1343), ...

BACKGROUND There have been few large epidemiological studies examining the association between thyroid dysfunction and cardiovascular disease. In particular, it is uncertain if subclinical hypothyroidism is a risk factor for cardiovascular disease. METHODS Serum thyrotropin and free thyroxine concentrations were measured in 2108 archived serum samples from a 1981 community health survey in Bu...

Background Diastolic dysfunction is traditionally believed to be the first subclinical manifestation of diabetic cardiomyopathy (DCM), leading systolic and then overt heart failure. However, in last few years, several studies suggested that measured by speckle-tracking echocardiography (STE) may appear ahead diastolic dysfunction. In this review, main endpoint show whether myocardial appears im...

WHY EARLY DIAGNOSIS? In corneal refractive surgery, early diagnosis of keratoconus (subclinical asymptomatic keratoconus) is of great importance in patients seeking surgery because it can prevent progression of the pathology after surgery and make it symptomatic (corneal ectasia), thus creating the need for diagnostic tests that provide high sensitivity (ability to detect the disease in affecte...

BACKGROUND Several epidemiologic studies have shown a possible association between thyroid function and cognitive decline. Our aim was to evaluate the association of subclinical hyperthyroidism and dementia in a population sample of older people METHODS A cross-sectional study--São Paulo Ageing & Health Study (SPAH)--in a population sample of low-income elderly people > or = 65 years-old to e...

WHY EARLY DIAGNOSIS? In corneal refractive surgery, early diagnosis of keratoconus (subclinical asymptomatic keratoconus) is of great importance in patients seeking surgery because it can prevent progression of the pathology after surgery and make it symptomatic (corneal ectasia), thus creating the need for diagnostic tests that provide high sensitivity (ability to detect the disease in affecte...

Mycobacterium avium subsp. paratuberculosis infection of cattle results in a chronic granulomatous enteritis. Clinical disease (i.e., cachexia, diarrhea, and high fecal bacterial counts) is preceded by a lengthy subclinical stage of disease. The immunologic mechanisms associated with the progression of infected cattle from subclinical to clinical disease are unclear. In this study, a cell proli...

purpose: to determine the sensitivity and specificity of posterior corneal elevation in discriminating keratoconus and subclinical keratoconus from normal corneas by galilei and orbscan ii diagnosed on the basis of topography. methods: three groups (keratoconus, subclinical keratoconus and normal) were evaluated with galilei and orbscan ii and results were compared to those obtained by gold sta...