نتایج جستجو برای: subclinical lv
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BACKGROUND Primary aldosteronism (PA) causes excess left ventricular (LV) hypertrophy and diastolic dysfunction; whether this occurs also in secondary aldosteronism (SA) without hypertension is unknown. We investigated the cardiac modifications in patients with preserved LV ejection fraction who had PA or SA. METHODS AND RESULTS We measured several Doppler echocardiography-derived variables, ...
BACKGROUND The metabolic syndrome has been associated with cardiovascular disease, but few studies have examined its relationship with subclinical measures such as echocardiographic left ventricular (LV) mass. This relationship is likely to be of particular importance in blacks, in whom both the metabolic syndrome and LV hypertrophy are common. METHODS AND RESULTS Echocardiography, performed ...
Results Sixteen age-matched subjects from the clinical pool with a low pre-test probability and normal CMR acted as a control group. Both groups had normal volumes and global systolic function (ejection fraction (%): control vs. SLE group: 60±13 vs. 56±12, p=0.57) and similar LV mass index (LVmass index (g/ m2): 43±12 vs. 51±12 g/ m2, p=0.18). SLE patients had significantly reduced longitudinal...
BACKGROUND Sarcomere protein mutations in hypertrophic cardiomyopathy induce subtle cardiac structural changes before the development of left ventricular hypertrophy (LVH). We have proposed that myocardial crypts are part of this phenotype and independently associated with the presence of sarcomere gene mutations. We tested this hypothesis in genetic hypertrophic cardiomyopathy pre-LVH (genotyp...
OBJECTIVES The purpose of our study was to determine structural and functional changes on left ventricular function (LV) according to body mass index (BMI) in normotansive overweight and obese children. STUDY DESIGN Thirty normotansive overweight children (group 2; mean age: 13.2 ± 2.1 years, BMI: 25-30 kg/m²), 30 obese children (group 3; mean age: 13.3 ± 2.0 years, BMI ≥ 30 kg/m²), and 50 he...
BACKGROUND Obesity and cardiometabolic dysfunction are associated with increased risk of heart failure and other cardiovascular diseases. We sought to examine the association of cardiometabolic traits with left ventricular (LV) cardiac mechanics. We hypothesized that specific obesity-related phenotypes are associated with distinct aspects of LV strain. METHODS AND RESULTS We evaluated the ass...
BACKGROUND Childhood obstructive sleep apnoea (OSA) is suggested to be associated with cardiac structural abnormalities and dysfunction but existing evidence is limited and the treatment effect on echocardiographic outcome remains controversial. OBJECTIVE To examine the presence of subclinical cardiac abnormalities in childhood OSA and the effects of treatment on cardiac changes. METHODS Po...
Pathological cardiac hypertrophy was produced by partial abdominal aortic constriction (PAAC) for 4 wk, while physiological cardiac hypertrophy was produced by chronic swimming training (CST) for 8 wk in rats. Pentoxifylline (30 mg/kg, 300 mg/kg i.p., day-1) treatment was started three days before PAAC and CST and it was continued for 4 wk in PAAC and 8 wk in CST experimental model. The left ve...
Chronic activation of the renin–angiotensin–aldosterone system is known to be associated with cardiovascular injury. Primary aldosteronism (PA), either from bilateral adrenal hyperplasia or an aldosterone-secreting tumor, is one of the principal causes of secondary hypertension. The combined vascular resistance and sodium retention lead to increased afterload and result in increased left ventri...
OBJECTIVE The objective of this study was to determine whether left ventricular (LV) myocardial deformation indices can detect subclinical abnormalities in Kawasaki disease convalescence. We hypothesized that subclinical myocardial abnormalities due to inflammation represent an early manifestation of the disease that persists in convalescence. BACKGROUND Myocardial inflammation has been descr...
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