To reduce the incidence of implant-associated infection, we previously developed a novel coating technology using hydroxyapatite (HA) containing silver (Ag). This study examined in vivo acute and subacute toxicity associated with the Ag-HA coating in rat tibiae. Ten-week-old rats received implantation of HA-, 2% Ag-HA-, or 50% Ag-HA-coated titanium rods. Concentrations of silver in serum, brain...

The primary departmental goal of preclinical toxicology (a.k.a. safety assessment) in drug development is to identify and characterize drug-induced toxicity in test animals by using appropriate animal models. This is accomplished through a large number of individual studies, sometimes referred to as a “tox package,” designed to provide specific data on the pharmacology/toxicology of the drug ca...

Previous research evaluating hydrocarbon toxicity to corals and coral reefs has generally focused on community-level effects, and results often are not comparable between studies because of variability in hydrocarbon exposure characterization and evaluation of coral health and mortality during exposure. Toxicity of the polycyclic aromatic hydrocarbon 1-methylnaphthalene to the coral Porites div...

Chrysanthellum americanum is a medicinal plant widely used in the North region of Cameroon for treatment epilepsy and convulsion. This study aimed to investigate acute subacute toxicity aqueous extract C. using experimental rodent models. For test, single dose 27.69, 69.22, 138.45, 276.9 5000 mg/kg was administered orally mice. In study, rats at doses 100, 250, 500 1000 mg/kg/day 28 days; final...

Purpose After peptide receptor radionuclide therapy (PRRT), renal toxicity may occur, particular in PRRTwith Y-labelled somatostatin analogues. Risk factors have been identified for increased probability of developing renal toxicity after PRRT, including hypertension, diabetes and age. We investigated the renal function over time, the incidence of nephrotoxicity and associated risk factors in p...

Aim of the study: The present study was carried out to evaluate the safety of ethanolic extract of celtis timorensis (EECT) by acute and sub-acute toxicity studies. Materials and Methods: Acute toxicity study was conducted in mice by using OECD 425 guidelines whereas sub-acute toxicity study was carried out in rats by using OECD 407 guidelines. In the acute toxicity study, mice were administere...