Gage, J. C. (1970). Brit. J. industr. Med., 27, 1-18. The subacute inhalation toxicity of 109 industrial chemicals. The inhalation toxicity of 109 substances has been studied by exposing experimental animals to known concentrations in air for periods of about three weeks. The toxic properties of these substances are reviewed in relation to the effects of similar compounds on animals and on man....

Subacute toxicity study of acetamiprid was undertaken in 72 female Wistar rats randomly divided into four groups (each consisting of 18individuals). Acetamiprid was administered orally @ 0, 25, 100 and 200 mg/kg of body weight to rats of Groups 1, 2, 3 and 4 respectively. Group 1 served as control. Calcium, sodium, potassium, chloride, zinc, copper, iron and cobalt were significantly increased ...

A 51 year old man developed progressive cranial and proximal muscle weakness, hyperreflexia and mental change. The disorder progressed over 9 days following the fifth weekly spraying with the organophosphate (OP) insecticide, phosmet, with limited symptoms of acute toxicity. Marked decremental responses of 50-80% on slow and fast rates of stimulation were improved to 15% by edrophonium or neost...

The first part of this report is devoted to recalling some very general concepts— indispensable for the understanding of the problems involved: 1. Concerning the different kinds of toxicity, acute, subacute, short term and long term, with special consideration of the consequences, mostly very insidious, of repeated exposure to poisons with cumulative properties. 2. Concerning the processes of a...

The management of diabetes is considered a global problem. FS002, a polyherbal Siddha formulation intended to be used for diabetic patients, has been screened for toxic effect. For sub-acute toxicity studies, different doses of FS002 were administered orally to rats once daily for 30 days. Animals were observed for physiological and behavioral responses, mortality, food, water intake and body w...

The present study was aimed at investigating the safety of Lacidipine (LCDP) loaded nanostructured lipid carriers (NLCs) in Wistar rats. NLCs were formulated using ultrasound dispersion technique. Animals were orally treated once daily with NLCs containing 0.140 mg, 0.350 mg, and 0.875 mg of LCDP as low, medium, and high dose per kg body weight, respectively, during 28 days along with blank for...

AIM The aim was to evaluate the effect of multiple oral administration of bisphenol A (BPA) for 28 days on seminal characteristic on mammal using Wistar rat as a model. MATERIALS AND METHODS Rats were randomly divided into five different groups having 6 male rats in each group. The doses chosen were 50, 200, and 600 mg/kg body weight for Groups III, IV and V, respectively, based on preliminar...

Neutralact(R), the DSM brand name of a lactase enzyme preparation, obtained from a homologous rDNA strain of Kluyveromyces lactis, was subjected to a series of toxicological tests to document the safety for use as a processing aid in the dairy industry. The enzyme preparation was examined for subacute oral toxicity and mutagenic potential. As a result of these tests, no evidence of oral toxicit...

An amino peptidase enzyme preparation obtained from Aspergillus niger was subjected to a series of toxicological tests to document the safety for use as a processing aid for food. The enzyme preparation was examined for subacute and subchronic oral toxicity, and mutagenic potential. No evidence of oral toxicity or mutagenicity was found. Administration of the amino peptidase enzyme preparation ...

Senna alata has attracted the attention of many researchers due to its numerous medicinal properties. This study aims to test the acute and sub-acute toxicity of its leaf extracts in Swiss albino mice. Studies were carried out with a fixed dose of 1,000, 2,000, and 3,000 mg/kg body weight through oral administration daily. Signs of toxicity in terms of behavior and mortality were noted after ev...