BACKGROUND: Neurorehabilitation technologies such as robot therapy (RT) and transcranial Direct Current Stimulation (tDCS) can promote upper limb (UL) motor recovery after stroke. OBJECTIVE: To explore the effect of anodal tDCS with uni-lateral and three-dimensional RT for the impaired UL in people with sub-acute and chronic stroke. METHODS: A pilot randomised controlled trial was conducted. St...

BACKGROUND Neurorehabilitation technologies such as robot therapy (RT) and transcranial Direct Current Stimulation (tDCS) can promote upper limb (UL) motor recovery after stroke. OBJECTIVE To explore the effect of anodal tDCS with uni-lateral and three-dimensional RT for the impaired UL in people with sub-acute and chronic stroke. METHODS A pilot randomised controlled trial was conducted. S...

BACKGROUND N-methyl-d-aspartate receptor (NMDAR) dysfunction is thought to contribute to the pathophysiology of schizophrenia. Accordingly, NMDAR antagonists such as phencyclidine (PCP) are used widely in experimental animals to model cognitive impairment associated with this disorder. However, it is unclear whether PCP disrupts the structural integrity of brain areas relevant to the profile of...

We studied whether MF59-adjuvanted influenza vaccine improves immunity against drifted influenza strains in institutionalised elderly with underling chronic health conditions. Sera from a randomized study, comparing MF59-adjuvanted (Sub/MF59, n = 72), virosomal (SVV, n = 39), and split (n = 88) vaccines, were retested using a hemagglutination inhibition (HI) assay against homologous (Northern H...

BACKGROUND Plaque psoriasis is a debilitating skin condition that affects approximately 2% of the adult population and for which there is currently no cure. Tofacitinib is an oral Janus kinase inhibitor that is being investigated for psoriasis. METHODS The design of this study has been reported previously (NCT00678210). Patients with moderate to severe chronic plaque psoriasis received tofaci...

This study evaluated the safety of rambutan rind extract (RRE) in male Wistar rats. While acute toxicity was evaluated by feeding the rats with single doses of RRE (1000, 2000, 3000, 4000, and 5000 mg/kg) and its sub-chronic toxicity was observed in rats orally administered with RRE (500, 1000, and 2000 mg/kg) daily for 30 days. In acute toxicity study, the LD50 was found to be greater than 500...

The erythrocytes deliver oxygen to all around body cells that make them extremely vital for the metabolism. Metals are transferred through the blood, meaning the erythrocytes face with metals continuously. The present study intended to explore the responses of osmoregulation (Na/K-ATPase, Mg-ATPase, Ca-ATPase) and antioxidant system parameters (CAT, SOD, GPX, GR, GST, tGSH, rGSH, GSSG, GSH/GSSG...

Fine particulate matter (PM2.5) is an important component of air pollution and can induce lung inflammation oxidative stress. We hypothesized that PM2.5 could play a role in the induction pulmonary fibrosis. examined whether multiple intranasal instillation fibrosis mouse, also investigated underlying pro-fibrotic signaling pathways. C57/BL6 mice were intranasally instilled with 50 ?l suspensio...