Rizvi,Ali, Xian-Liang Tang, Yumin Qiu, Yu-Ting Xuan, Hitoshi Takano, Asad K. Jadoon, and Roberto Bolli. Increased protein synthesis is necessary for the development of late preconditioning against myocardial stunning. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H874–H884, 1999.—In phase I of this study, the rate of protein synthesis was measured by the incorporation of [3H]leucine into the p...

Recent studies suggest that the hydroxyl radical (-OH) plays a pathogenetic role in postischemic ventricular dysfunction (myocardial "stunning"). This concept, however, is predicated exclusively on results obtained in anesthetized open-chest preparations, which are subject to the confounding influence of many unphysiological conditions and in which both myocardial stunning and free radical gene...

Although protein tyrosine kinases (PTKs) signaling has been implicated in the late phase of ischemic preconditioning (PC), it is unknown whether PTK signaling is necessary for the development of nitric oxide (NO) donor-induced late PC. Thus conscious rabbits underwent a sequence of six 4-min coronary occlusion (O)/4-min reperfusion (R) cycles followed by a 5-h recovery period of reperfusion for...

In the last decade, public interest in welfare of decapod crustaceans has increased many parts world. This led to changes legislation on methods for slaughter a number countries, while others pressure regulation is growing. Electro-stunning may have potential reducing noxious stimuli experienced by during slaughter. However, data activity central nervous system (CNS) and product quality-related...

Kodani, Eitaro, Yu-Ting Xuan, Ken Shinmura, Hitoshi Takano, Xian-Liang Tang, and Roberto Bolli. -Opioid receptor-induced late preconditioning is mediated by cyclooxygenase-2 in conscious rabbits. Am J Physiol Heart Circ Physiol 283: H1943–H1957, 2002. First published July 26, 2002; 10.1152/ajpheart.00150.2002.—Although activation of -opioid receptors is known to induce both early and late preco...

Thyroid stunning has been reported as the temporary impairment of thyroid tissue after a 111-MBq or greater diagnostic 131I dose that decreases the final absorbed dose in ablative therapy. Concerns regarding the reality of stunning have arisen in part due to a flawed study design in prior reports. To assess whether a stunning effect has any impact on therapeutic outcomes, we compared initial tr...

BACKGROUND Myocardial hibernation and stunning are characterised by a reversible contractile dysfunction during and after ischaemia, respectively. Calcium homeostasis might be disturbed in hibernation and stunning due to altered expression of cardiac proteins involved in calcium handling. METHODS In enflurane-anaesthetised swine the coronary blood flow through the left anterior descending cor...

Incomplete recovery of myocardial contraction after reperfusion following brief ischemia is called the "stunning phenomenon" in an animal experiment. A hydrophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin) does not affect this phenomenon, but lipophilic statins further reduce the contraction during reperfusion. The effects of novel hydrophilic rosuvastatin and...

Both percussive and electrical stunning have been highlighted as methods that can be used to quickly render fish unconscious before being killed. However, accurately assessing unconsciousness in animals following remains challenging, thus for reliable interpretation validation of different are urgently needed. Here, we a non-invasive technique continuously record electroencephalograms (EEG) rai...

The mechanism(s) underlying contractile dysfunction in cardiac stunning is not completely understood. The expression and/or the phosphorylation state of cardiac Ca(2+) homoeostasis-regulating proteins might be altered in stunning. We tested this hypothesis in a well-characterized model of stunning. Conscious dogs were chronically instrumented, and the left anterior descending artery (LAD) was o...