Protein-protein interactions are central to most biological processes. Although much recent effort has been put into methods to identify interacting partners, there has been a limited focus on how these interactions compare with those known from three-dimensional (3D) structures. Because comparison of protein interactions often involves considering homologous, but not identical, proteins, a key...

RecA protein is a hallmark for the bacterial response to insults inflicted on DNA. It catalyzes the strand exchange step of homologous recombination and stimulates self-inactivation of the LexA transcriptional repressor. Importantly, by these activities, RecA contributes to the antibiotic resistance of bacteria. An original way to decrease the acquisition of antibiotic resistance would be to bl...

This article reviews and summarizes recent work on flow-structural interaction in solid motors. This interaction is important because it can lead to rocket motor failure. In the first part of the document, an idealized model of the failure mechanism is developed to illustrate in simple terms how such an event can occur. In the second part of this article recently published numerical modeling wo...

An important eld in computational science and engineering is the simulation of the coupled problem of uid ow interacting with a moving structure. A common notation for this is uid-structure interaction (FSI) problems, which include both aeroelasticity and hydroelasticity. Such multi-physics systems have received renewed attention as a result of the increase in length of slender structures e.g. ...

Neurabin and spinophilin are neuronal scaffolding proteins that play important roles in the regulation of synaptic transmission through their ability to target protein phosphatase 1 (PP1) to dendritic spines where PP1 dephosphorylates and inactivates glutamate receptors. However, thus far, it is still unknown how neurabin and spinophilin themselves are targeted to these membrane receptors. Spin...

Determining protein interaction networks and predicting network changes in time and space are crucial to understanding and modeling a biological system. In the past few years, the combination of experimental and computational tools has allowed great progress toward reaching this goal. Experimental methods include the large-scale determination of protein interactions using two-hybrid or pull-dow...

We present a structural framework to describe games in terms of components. The components are divided into four major areas: meta-structure, bounding, narrative and objective. The framework is developed to be used in conjunction with game design patterns, descriptions of patterns of interaction relevant to game play. We describe the development of the framework and how it relates to patterns.

Social reward dependence (RD) in humans is a stable pattern of attitudes and behaviour hypothesized to represent a favourable disposition towards social relationships and attachment as a personality dimension. It has been theorized that this long-term disposition to openness is linked to the capacity to process primary reward. Using brain structure measures from magnetic resonance imaging, and ...

an important problem in performance evaluations of irrigation systems is the difficulty of the determining share of structural and operational elements and determining improvement solutions. in most studies, the combined impact of structural and operational elements on the performance of irrigation systems is assessed. some researchers try to separate the effects of structural and operational e...

background: glycation of proteins is a non-enzymatic spontaneous process that occurs in diabetes mellitus and aging, altering the structure and function of proteins. igg undergoes glycation leading to changes in its reactivity to antigen and fixation of complement.   objective: this study aimed at revealing the effect of glycation on the interaction of igg with anti-igg using electroimmunoassay...