نتایج جستجو برای: structural dependent biological activity

تعداد نتایج: 2375451  

Objectives: Aim of the present work was to investigate the anti-inflammatory, analgesic and antiulcer effects of red seaweed Porphyra vietnamensis (P. vietnamenis). Materials and Methods: Aqueous (POR) and alcoholic (PE) fractions were successfully isolated from P. vietnamenis. Further biological investigations were performed using a classic test of paw edema induced by carrageenan, writhing in...

Fatemeh Shafiei

It is well known that the chemical behavior of a compound is dependent upon the structure of itsmolecules. Quantitative structure – activity relationship (QSAR) studies and quantitative structure –property relationship (QSPR) studies are active areas of chemical research that focus on the nature ofthis dependency. Topological indices are the numerical value associated with chemical constitution...

Journal: :modares journal of medical sciences: pathobiology 2007
yasamin danaee mehrdad behmanesh majid sadeghizadeh

objective: the itpa gene is responsible to remove free deaminated purine nucleotides of itp, ditp and xtp from nucleotide pool of the cells. it seems that dysfunction in its activity, not only can increas the base substitution mutations frequency but also can works as a contrived factor to creating instability in genetic materials of the cells. there are several reports about the existence of s...

Journal: :Neuron 2008
Nadine Becker Corette J. Wierenga Rosalina Fonseca Tobias Bonhoeffer U. Valentin Nägerl

Activity-dependent changes in the synaptic connections of the brain are thought to be important for learning and memory. Imaging techniques have enabled the examination of structural rearrangements during activity-dependent processes at the synapse. While many studies have examined structural changes of dendritic spines, little is known about structural plasticity of presynaptic boutons. We the...

Journal: :The Journal of pharmacology and experimental therapeutics 2010
B J Yamamoto P D Elias J A Masino B D Hudson A T McCoy Z J Anderson M D Varnum M F Sardinia J W Wright J W Harding

The angiotensin (Ang) IV analog norleual [Nle-Tyr-Leu-psi-(CH2-NH2)(3-4)-His-Pro-Phe] exhibits structural homology with the hinge (linker) region of hepatocyte growth factor (HGF) and is hypothesized to act as a hinge region mimic. Norleual competitively inhibited the binding of HGF to its receptor c-Met in mouse liver membranes, with an IC(50) value of 3 pM. Predictably, norleual was able to i...

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