in this investigation, diabetes was induced in adult male sprague-dawley rats by single intraperitoneal injection of streptozotocin (stz) at 45 mg kg-1 of body weight. a group comprised of 8 diabetic rats was treated with metformin at 100 mg kg-1 of body weight for reducing the elevated blood glucose level. the results revealed that, in the untreated diabetic rats, the body and testicular weigh...

The effects of systemic insulin administration at different concentrations on the testicular tissue diabetic adult rats, induced by streptozotocin, are evaluated morphological analysis spermatogenic process. Twenty-four male rats were divided into 1) Control Group: they received citrate buffer, intraperitoneal injection; 2) Diabetic injection streptozotocin (60 mg. kg-1 body weight); 3) Insulin...

Aim: Diabetes Mellitus is a global public health challenge with major and potentially devastating complications, concomitant complications include retinopathy neuropathy due to hypoxia microvascular dysfunction. In this study, we investigated the effect of hyperbaric oxygen therapy as method transiently improve tissue oxygenation on diabetic in streptozotocin induced type-1 rat model (Wistar). ...

Penelitian ini bertujuan untuk melakukan kajian praklinis efek antidiabetes dari ekstrak etanol herba Tridax procumbens (Asteraceae) pada tikus diabetes yang diinduksi streptozotocin. Prosedur penelitian dimulai dengan mengumpulkan sampel uji Linn (TP). Seluruh bagian tanaman TP telah dikeringkan diekstraksi (95%) cara dimaserasi selama 72 jam, selanjutnya dilakukan skrining fitokimia mengetahu...

Guizotia abyssinica Cass. widely grown plant of southern India, seed oil which are said to be healthy source oil. Diabetes mellitus is a metabolic disorder affecting major population worldwide. Nutritive oils and fats essential in current scenario. Hence antidiabetic property Cass tested Streptozotocin induced diabetes Wistar albino Rats. Materials methods: Test drug collected, authenticated, p...

Reduction of the nitroso group in streptozotocin (1a) has led to cyclized products rather than a semicarbazide (1c). Some analogs (1e, 9a, 9b, 9c and 9d) of streptozotocin in which the nitroso group was replaced by other groups have been prepared.

BACKGROUND Stevia rebaudiana Bertoni has been used for the treatment of diabetes in, for example, Brazil, although a positive effect on antidiabetic and its complications has not been unequivocally demonstrated. This herb also has numerous therapeutic properties which have been proven safe and effective over hundreds of years. Streptozotocin is a potential source of oxidative stress that induce...

Mammalian reproduction is dynamically regulated by the pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones are synthesized in the pituitary gland following stimulation by the gonadotropin-releasing hormone (GnRH) and act by stimulating steroid production and gametogenesis in both males and females. Male adult Sprague-Dawley rats (120 - 140 g)...