Meyer and Quan (1949) have demonstrated amply the therapeutic efficacy of streptomycin in experimental bubonic and pneumonic plague. Since streptomycin appears to be unique among the antibiotics in that high levels of resistance may occur in bacteria at a single mutational step (Bryson and Demerec, 1950), the occurrence of strains of Pasteurella pestis so resistant to this antibiotic as to be r...

Banerjee, Arun B. (University of Calcutta, Calcutta, India), and S. K. Bose. Biosynthesis of mycobacillin, a new antifungal peptide. II. Relation between streptomycin dependence and biosynthesis. J. Bacteriol. 87:1402-1405. 1964.-A streptomycin-dependent variant was isolated by a single-step mutation process from a strain of Bacillus subtilis capable of producing mycobacillin, a cyclic polypept...

Lowell’ gave the incidence of allergy to streptomycin as 10 per cent. This high incidence is due to administration of the drug for long periods in tuberculosis. Most of the allergic reactions were not serious. There was no way of knowing whether a patient allergic to streptomycin could react again on re-administration. It might be assumed that he would. Houghton2 in England and Chakravarty3 in ...

Streptomycin is the treatment of choice in developing countries for patients suffering from tuberculosis or other infectious diseases. However, it produces incapacitating vestibular symptoms whose onset is delayed and gradual. This observation led to the notion that a streptomycin metabolic derivative and not the antibiotic itself is the damaging agent for the inner ear. To study further the ex...

We reported previously that D-glucosamine or a close derivative was involved in the synthesis of the N-methyl-L-glucosamine moiety of streptomycin'). Since D-glucosamine is a component of the cell wall of streptomycetes2,3), this sugar or its derivatives may be a common precursor of streptomycin and the cell wall. We studied also whether UDP-N-methyl D glucosaminephosphate was involved in the s...