Many reports can be obtained on the mechanism for the Maillard reaction between amino acids and reducing sugars. Most of these reports have concentrated on the early stage of this reaction, including the formation of N-glucosides, Amadori rearrangement and the decomposition of Amadori compounds.i) In consequence, various intermediates have been identified, whose roles in the advanced stage of t...

Spirohydantoins are considered privileged structures, making them attractive for the preparation of compound libraries with the potential for diverse biological activity. However, very few modifications of this scaffold have been reported to date. The spirohydantoin template was elaborated into a library of 168 compounds through a two-step solution-phase parallel synthesis starting from various...

New N-substituted ?-aminonitrile derivatives from menthol were synthesized by consecutive succinic ester formation, propargylation, 1,3-dipolar Huisgen cycloaddition and Strecker reaction. The structures of the compounds confirmed diverse spectroscopic techniques including 1HNMR, 13C-NMR, ESI-MS IR. novel evaluated for their in vitro antibacterial activities against Staphylococcus aureus as Gra...