Fasting gastric juice pH and concentrations of vitamin C in gastric aspirate and plasma were measured in 73 patients undergoing endoscopy. Vitamin C concentrations were significantly lower in those with hypochlorhydria (pH greater than 4; n = 23) compared with those with pH less than or equal to 4 (p less than 0.005) and there was a significant correlation between gastric juice and plasma conce...

Fenwick (1870) was the first to discover that patients with pernicious anaemia have a deficiency of gastric pepsin, and this observation has been amply confirmed (Stockton, 1904; Levine and Ladd, 1921 ; Teschendorf, 1927; Faber, 1927; Faber and Holst, 1928 ; Johansen, 1929; Polland and Bloomfield, 1930; Castle, Heath, and Strauss, 1931 ; Davies, 1931 ; Wilkinson, 1932; Helmer, Fouts, and Zerfas...

The existence of more than one gastric pepsin has been reported by many authors. Herriott, Desreux, and Northrop (1940) separated two proteolytic fractions from human gastric juice by salt-fractionation methods, and similar results were described by Baker (1951) and Taylor (1959b). Using moving boundary electrophoresis, Kushner, Rapp, and Burtin (1964), Merten, Schramm, Grassmann, and Hannig (1...

Of late years many new procedures have been introduced with the object of improving our methods of diagnosis in gastric affections by direct analysis of the gastric juice, and of thus enabling us by the light of more exact knowledge of the morbid process to interfere with greater precision and success. The methods employed?which, roughly speaking, consist in the withdrawal of a portion of the s...

Objective: This study investigates the behavior of two different radionuclide labels for liquid test meals and the stability of radionuclide labeling of solid meals. Methods: Technetium-99m DTPA and mTc colloid were compared as labels for liquid test meals in an in vivo investigation of gastric emptying rate. Half emptying time and retention percentages were used as parameters. Stability of sol...

Pancreatic secretory trypsin inhibitor (PSTI) is a potent protease inhibitor that also has growth promoting activity. It has recently been identified in the foveolar cells of the stomach, which secrete mucus. We examined the effects of the prostaglandin E1 analogue misoprostol on gastric PSTI output. Seven normal volunteers took part. An initial period of gastric aspiration was followed by four...

PURPOSE: Scorpion toxin purified from Tityus serrulatus venom (Tx) induces an increase in volume, acidity and pepsin secretion in the gastric juice of rats. Ligation of oesophagus has been shown to reduce the acid gastric secretion in rats. The aim of this paper was to determine the influence of the esophageal ligation on gastric secretion induced by Tx in rats METHODS: Forty-four male albino r...

Helicobacter pylori organisms that infect the stomach conceivably could contribute to esophageal inflammation in patients with gastroesophageal reflux disease (GERD) through any of at least three potential mechanisms: 1) by causing an increase in gastric acid secretion; 2) by spreading to infect the gastric-type columnar epithelium that occasionally can line the distal esophagus; and/or 3) by s...

Helicobacter pylori (Hp) is a major causative factor for gastric disorders and epidemiological evidence has accumulated indicating a significant relationship with chronic active gastritis, peptic ulcer, atrophic gastritis, intestinal metaplasia, and lymphoma or cancer development (Marshall and Warren, 1984; Nomura et al., 1991; Uemura et al., 2001). In 1994, the World Health Organization/ Inter...