Background: UBX domain-containing protein 4 (UBXN4) was discovered for the first time because its domain can interact with p97/VCP to participate in endoplasmic reticulum-associated degradation (ERAD). Although there are many reports that family is involved occurrence and development of tumors, a pan-cancer analysis UBXN4 not yet available. Material Methods: We explored potential carcinogenic e...

The study aimed to investigate the antitumor efficacy of anti-LMP1 antibodies in EBV-positive nasopharyngeal and stomach cell lines xenograft models. also examined NF-κB expression cycle activation NPC-serum-exosome-associated LMP1. Anti-LMP1 antibody treatment before or during implantation prevented tumor growth nude mice. A small dose resulted complete regression for at least three months aft...

RATIONALE The synchronous occurrence of lung cancer in patients with gastric neoplasms is relatively uncommon, especially the cases of synchronous coexistence of small cell lung carcinoma and diffuse large B-cell lymphoma of the stomach. PATIENT CONCERNS We encountered a case of synchronous primary small cell lung carcinoma and diffuse large B-cell lymphoma of the stomach. A 63-year-old patie...

Cancer starts with a change in one single cell. This change may be initiated by external agents and genetic factors. Cancer is a leading cause of death worldwide and accounts for 7.6 million deaths (around 13% of all deaths) in 2008. Lung, stomach, liver, colon and breast cancer cause the most cancer deaths each year. In this review, different aspects of gastric cancer; including clinical, path...

Etiology and the disease process: Chronic inflammation of the stomach in response to untreated H. pylori infection lasting many years leads to the atrophy of stomach cells and a corresponding loss of acid-secreting capacity. Some patients may be more predisposed to achlorhydria in the presence of H. pylori because they respond to the infection by producing a specific inflammatory agent that is ...

Although positive associations have been found for diabetes and a number of cancer sites, investigations of stomach cancer are limited and the results lack consistency. In this prospective study we investigated the relationship between type 2 diabetes mellitus (T2DM) and stomach cancer risk in mainland China. We assessed the associations among T2DM, T2DM duration, and stomach cancer risk in two...

Human hybridoma technologies permit the cloning of patient antibodies that may have desirable qualities. In this study, we report the isolation of a natural IgG antibody from a stomach cancer patient that illustrates novel diagnostic and therapeutic uses. Human antibody PAT-BA4 recognizes a tumor-specific variant of the transcription factor TATA-binding protein-associated factor 15 (TAF15) that...

STUDY OBJECTIVE To study the association between socioeconomic status (SES) and stomach cancer incidence (cardia and non-cardia) and the role of lifestyle factors in explaining this association. DESIGN Prospective cohort study on diet and cancer that started in 1986. Data were collected by means of a self administered questionnaire. SETTING Population originating from 204 municipalities in ...

Cancer is a genetic disorder that results from or epigenetic alterations in the somatic cells and has abnormal cell growth which may be spread to other body parts. In 2018, 18 million cancer was recorded globally 9.5 cases men, 8.5 women, 9.6 deaths were also same year. The most spreading prostate, breast, lung stomach, colorectal cancer, non-melanoma skin malignancies but there are 100 types o...

We carried out a case-control study is to investigate the relationship between iodine deficiency and stomach cancer. We compared the ratio of urinary iodine to urinary creatinine in 100 patients diagnosed with stomach cancer and 84 people in a control group. Mean urinary iodine levels were lower in the patients with stomach cancer, 61.9 microg/g creatinine, compared to 101.7 microg/g creatinine...