A fuzzy-decision-making procedure is applied to find the optimal feed policy of a fed-batch fermentation process for L-lysine production in a stirred tank bioreactor from Brevibacterium flavum 22LD. The policy consists of a feed flow rate, feed concentration of glucose and threonine, and fermentation time. In this paper the fermentation process is formulated as a general multiple objective opti...

This paper presents the design and the analysis of some adaptive nonlinear control strategies for a class of depollution fermentation processes that are carried out in a continuous stirred tank bioreactor. The controllers design is based on the input-output linearization technique. The resulted control methods are applied in depollution control problem in the case of the anaerobic digestion bio...

Background The commercial success of mammalian cell-derived recombinant proteins has fostered an increase in demand for novel single-use bioreactor (SUB) systems, that facilitate greater productivity, increased flexibility and reduced costs. Whilst maintaining auspicious mixing parameters, these systems exhibit fluid flow regimes unlike those encountered in traditional glass/stainless steel bio...

Introduction Disposable bioreactors are increasingly gaining acceptance for cell culture applications due to a number of advantages including ease of use and reduced labour costs, less requirements for utilities such as steam and purified water. In addition, the system requires no cleaning or cleaning validation and only a reduced clean room footprint. Integrated ready to use pre-sterilised dis...

The non-isothermal continuous stirred tank reactor (CSTR) is a classical yet complex case study of nonlinear dynamical systems. Power-shaping control is a recent approach for the control of nonlinear systems based on the physics of the dynamical system and it rests on the formulation of the dynamics in the Brayton-Moser form. The Brayton-Moser formulation of the non-isothermal continuous stirre...

In this paper the design of a nonlinear feedback controller is analyzed for concentration control of continuous stirred tank reactors (CSTR) which have strong nonlinearities. Continuous Stirred Tank Reactor (CSTR) is one of the common reactors in chemical process and all industrial process requires a solution of specific chemical strength of chemicals considered for analysis. Here Particle Swar...

Rationale and significance. Recombinant therapeutic proteins are frequently produced in mammalian cells cultivated in suspension in large-scale stirred tank bioreactors. There are three major drawbacks to stirred-tank bioreactors. First, they are expensive to purchase and maintain, limiting their availability to some potential users. Second, they have not been adapted to volumetric scales less ...

In this work the Computational Fluid Dynamics simulation of a stirred bioreactor purposely designed for the production of hydrogen from organic wastes fermentation is presented. The bioreactor is a vortex-ingesting, dual impeller, mechanically-agitated vessel equipped with a central draft tube. Due to the geometrical and physical complexity, the selected reactor offers a very challenging benchm...