Many pathogenic microorganisms invade mammalian and/or plant cells by producing polysaccharide-degrading enzymes (lyases and hydrolases). Mammalian glycosaminoglycans and plant pectins that form part of the cell surface matrix are typical targets for these microbial enzymes. Unsaturated glycoside hydrolase catalyzes the hydrolytic release of an unsaturated uronic acid from oligosaccharides, whi...

BACKGROUND Da Chengqi Tang (DCT) is a common purgative formula in Chinese medicine. Flavanones are its major active compounds derived from Fructus Aurantii Immaturus. The present study developed an LC-MS/MS method to characterize two pairs of flavanone 7-glycoside isomers, i.e., hesperidin versus neohesperidin and naringin versus isonaringin. METHODS After solid phase purification, components...

BACKGROUND Rhubarb is an important Chinese medicinal herb with a long history of over 2000 years and has been commonly used as a laxative. It is the radix and rhizome of Rheum officinale Baill., R. palmatum L. and R. tanguticum Maxim, all of which are mainly distributed in a broad region in the Tibetan plateau. Anthraquinone glycosides are a series of major active ingredients found in all three...

This study aimed to investigate the effects of flavonoid glycoside on mitochondrial dysfunction and inflammatory oxidative stress in macular degeneration. Sixty specific-pathogen-free male Bagg Albino mice were randomly divided into control, model glycoside. Human retinal pigment epithelium cells ARPE-19 cultured treated with dimethyl sulfoxide, sodium iodate respectively. Fundus fluorescein an...

Stevia rebaudiana B. extracts as a low-calorie sweetener have gained worldwide approval. Synthesized nanoparticles by plant were used in different programs such as medical, pharmaceutical and agricultural filed. Here, we report the increase of the main glycosides of stevia plant with silver nanoparticles (AgNPs) treatment. This fact has stimulated the research on the analysis and comparison of ...

Antioxidants are compounds which can prevent biological and chemical substances from oxidative damage by reactive oxygen species. Flavonoids are the most important class of polyphenolic compounds that because of their antioxidant characters possess biological activities and pharmacological effects. Chrysin-6-C-fucopyranoside and chrysin-3-malonyl-6-C-fucopyranoside are mono C-glycosyl derivativ...

Whether hydrolytic or synthetic, glycosyl transfer is, simply in terms of quantity, one of the most important biological reactions on earth. The formation and cleavage of glycosidic bonds are catalysed by glycosyltransferases and glycoside hydrolases which are crucial for a number of biological pathways (biosynthesis and degradation of structural and storage polysaccharides, cellular signalling...

Sitosterol, campesterol, stigmasterol, and cholesterol were isolated from green wheat (Triticium aestivum var. Monon) seedlings. Sitosterol was the predominant sterol extracted from the shoot, root, and crown tissue. Cholesterol accounted for less that 1% of sterol in shoot tissue with only trace amounts in the root. A temperature change from 10 to 1 C resulted in a general decrease in sitoster...

The current research has centered on the use of pharmacological and binding affinity methods to test 36 compounds as bioactive constituents’ inhibitors for COVID-19. Six out phytoconstituents (rutin, quercetin, catechin gallate, rhamnetin, campesterol stigmasterol) have demonstrated outstanding molecular docking drug-like properties HIV Lopinavir Indinavir. Interestingly, lowest energies (LBE) ...