Background: Cancer is one of the biggest health problems worldwide, with lung cancer as first rank in number new cases and deaths. Non-small cell carcinoma (NSCLC) a type that accounts for about 85% all cases. Previous research identified role epidermal growth factor receptor (EGFR) most suitable target to treat NSCLC. This study aims identify potential compounds derived from mangrove plants ag...

Four phytoecdysteroids: (20-hydroxyecdysone-20, 22-monacetonide (1), 20-hydroxyecdysone (2), stigmasterol (3), gamma-sitosterol (4), were investigated for toxic effect against 3 rd /4 th instar larvae of Anopheles gambiae under laboratory conditions as individual compounds and in blends. The test larvae were treated with solutions containing the phytoecdysteroids of concentrations 1, 5 and 10pp...

Alcohols and hydrogen peroxide altered the permeability of membranes of Beta vulgaris root cells. Generally alcohols increased the permeability of membranes without going through an induction period except methanol which required a 10- to 15-hour induction period. The membrane effect of methanol could be inhibited with CaCl(2), cholesterol, beta-sitosterol, and stigmasterol. Cholesterol was the...

Ethyl acetate fraction column chromatographic analysis was used to isolate eleven compounds (numerically tagged 1–10) from Cassia occidentalis L. in this study. Two unique metabolites, including a neolignan compound designated as occidentalignan I (9) and flavonoidal glycoside, chrysin-7-O-α-L-rhamnopyranosyl (10), were identified, while silybin A (8) the first flavonolignan be isolated Fabacea...

The powdered roots of the medicinal plant Acacia nilotica were extracted with hexane and ethyl acetate, extracts subjected to column chromatography for isolation potentially bioactive compounds their screening against kinetoplastid pathogens. NMR HREI mass spectrometric analyses identified two new diterpenes, characterized as 16, 19-dihydroxycassa-12-en-15-one (Sandynone, 1 ) (5S, 7R, 8R, 9R, 1...

Here we use nuclear magnetic resonance to measure the solubility limit of several biologically relevant sterols in electroformed giant unilamellar vesicle membranes containing phosphatidylcholine (PC) lipids in ratios of 1:1:X DOPC:DPPC:sterol. We find solubility limits of cholesterol, lanosterol, ergosterol, stigmasterol, and β-sitosterol to be 65-70%, ~35%, 30-35%, 20-25%, and ~40%, respectiv...

Thirteen fatty acids were identified from the pulps of four Tunisian Ziziphus jujuba ecotypes (Sfax, Choutrana, Mahres and Mahdia), using capillary gaseous chromatography method. These oils presented 8.31% to 12.35% of dry weights. Compared to the other ecotypes, Mahres and Choutrana were the richest of the oleic acid. The palmitic acid was the most important compound of the Sfax ecotype. Unsat...