Summary Immune checkpoint blockade (ICB) has fundamentally improved the treatment landscape of advanced lung cancer. Improved tolerability and encouraging duration response in selected patients are some advantages ICB over conventional cytotoxic chemotherapies. However, immune-related adverse events (irAEs) possibly affecting multiple organs pose challenges diagnosis management. Checkpoint inhi...

Background: Pulse therapy is a type of systemic management in which large amounts of medications are administered to patients in short time and intervals (e.g. weekly) to get the stronger effects of medication sooner and avoid long term use of them. Objective: To determine how therapy-resistant dermatology diseases respond to oral minipulse steroids . Methods: Articles with Mesh terms "pulse th...

Glandular fever or infectious mononucleosis is a disease of undetermined aetiology which may present variously. The literature is replete with accounts of its complications. In spite of the usually benign course, there remains a small mortality rate and it is therefore not surprising that adrenal corticosteroid treatment has been used in the severest forms of the illness. Doran et al.3 describe...

Addison’s disease or autoimmune adrenalitis: These are autoimmune conditions, constituting 80% of all cases. Autoimmune adrenalitis may be part of Type 2 autoimmune polyglandular syndrome, which can include type 1 diabetes, hyperthyroidism, and autoimmune thyroid disease (also known as Hashimoto’s thyroiditis), and Hashimoto’s disease. Hypogonadism may also present with this syndrome. Other dis...

Steroid therapy in patients with septic shock has been controversial for decades. Although treatment with high-doses of corticosteroids for patients with septic shock has been shown not to be beneficial, it was believed that therapy with low-doses would be helpful. Recent studies document that steroids are beneficial only in adult septic shock patients whose blood pressure is poorly responsive ...

recalcitrant gingival erythematous lichen planus lesions comprise a considerable therapeutic problem. this case of chronic desquamative gingivitis in a 25-year-old woman with erosive oral lichen planus was treated with topical and systemic corticosteroid administration, followed by placement of a free gingival graft on right upper quadrant. although recurrence of the lesions was observed follow...

We treated a 27-year-old man with Heerfordt's syndrome and hearing loss. Physical examination showed swelling of both parotid glands, right peripheral facial palsy and uveitis(iridocyclitis), but no skin lesions. Chest X-ray showed typical bilateral hilar lymphadenopathy. Biopsies of the parotid gland and the gastrocnemius muscle showed epithelioid granulomas. The above findings were consistent...