AIMS To compare the efficacy and safety of two titration algorithms for insulin degludec/insulin aspart (IDegAsp) administered once daily with metformin in participants with insulin-naïve Type 2 diabetes mellitus. METHODS This open-label, parallel-group, 26-week, multicentre, treat-to-target trial, randomly allocated participants (1:1) to two titration arms. The Simple algorithm titrated IDeg...

When managing their growing service portfolio, many manufacturers in B2B markets face two significant problems: They fail to communicate the value of their service offerings to their customers, and they lack the capabilities to generate profits with value-added services. To tackle these two issues, we design and evaluate a collaborative filtering recommender system which (a) makes individualize...

MP systems are a class of P systems introduced for modeling metabolic processes. Here we apply an algorithm, we call Log-Gain Stoichiometric Stepwise Regression (LGSS), to Golbeter’s oscillator. In general, LGSS derives MP models from the time series of observed dynamics. In the case of Golbeter’s oscillator, we found that by considering different values of the resolution time τ , different ana...

We present a method for enabling the researcher to create empirically informed, and thus realistic, random trajectories between two endpoints. The method used relies on empirical distribution functions, which define a dynamic drift expressed in a stepwise joint probability surface. We create random discrete time-step trajectories that connect spatiotemporal points while maintaining a predefined...

In this paper we continue our study on adaptive genetic programming. We use Stepwise Adaptation of Weights (saw) to boost performance of a genetic programming algorithm on simple symbolic regression problems. We measure the performance of a standard gp and two variants of saw extensions on two different symbolic regression problems from literature. Also, we propose a model for randomly generati...

This paper concerns the estimation algorithm for hinging hyperplane (HH) models, a non-linear black box model structure suggested in 3]. The estimation algorithm is analysed and it is shown that it is a special case of a Newton algorithm applied on a quadratic criterion. This insight is then used to suggest possible improvements of the algorithm so that convergence can be guaranteed. In additio...

BACKGROUND/AIM Management of dyspepsia may differ between countries. In Japan, Helicobacter pylori infection should be considered because of the high prevalence of the infection and the related diseases. I tried to propose an algorithm for stepwise diagnosis and treatment from uninvestigated dyspepsia to functional dyspepsia in clinical practice in Japan. METHODS A proposal was made from my p...

Cogeneration system is a nonlinear multivariate system with a wide operating regime. The efficiency of electricity generating and thermoelectric conversion coefficient of turbine generator are affected by many factors such as load variation, extracted steam change, and unstable supplied power etc. In this paper, a kind of identification algorithm has been proposed to build the statistical model...

We introduce rt-inconsistency, a property of real-time requirements. The property reflects that the requirements specify apparently inconsistent timing constraints. We present an algorithm to check rt-inconsistency automatically. The algorithm works via a stepwise reduction to real-time model checking. We implement the algorithm using an existing module for the reduction and the UPPAAL tool for...

Real solution classification of parametric polynomial systems is a crucial problem in real quantifier elimination which interests Volker Weispfenning and others. In this paper, we present a stepwise refinement algorithm for real solution classifications of a class of parametric systems consisting of polynomial equations, inequalities and inequations. For an input system, the algorithm outputs t...