A sucrose-rich diet (SRD), compared with a starch diet, induces time-dependent metabolic disorders and insulin resistance with hypertriglyceridemia, similar to type 2 diabetes. In this study, we examined the effect of SRD, after 8 mo, on nuclear receptors peroxisome proliferator-activated receptor-alpha (PPARalpha), and liver X receptor-alpha (LXRalpha), stearoyl-CoA desaturase-1 (SCD-1), and D...

Excessive ethanol intakes have been reported to be linked liver diseases such as hepatitis and cancerrelated of ethanol. can lead the accumulation reactive oxygen species(ROS) depletion glutathione (GSH) in liver. Ethanol-induced oxidative stress substantiallyincreases peroxidation lipid decreases GSH levels human hepatocyte animal models.Ethanol contributes sterol regulating element-binding pr...

Abstract The nutritional quality of milk, which is determined by its fatty acid (FA) composition, and the candidate gene stearoyl-CoA desaturase (SCD) can be used in conjunction with these traits to improve dairy products. aim this study was identify single nucleotide polymorphism (SNP) SCD associations milk composition FA profiles Najdi sheep 72 multiparous ewes under same feeding system. Milk...

We hypothesized that supplementing finishing diets with palm oil would promote adipogenic gene expression but depress stearoyl-CoA desaturase (SCD) gene expression in intramuscular (i.m.) adipose tissues of Hanwoo steers during fattening period (from 16 to 32 mon of age). Fourteen Hanwoo steers were allotted randomly to 2 groups of 7 steers based on initial BW and fed either a basal diet (contr...

Stearoyl-coenzyme A desaturase (SCD) is a key regulator of membrane fluidity, turns over rapidly, and represents a prototype for selective degradation of resident proteins of the endoplasmic reticulum. Using detergent-solubilized, desaturase-induced rat liver microsomes we have characterized a protease that degrades SCD. Degradation of SCD in vitro is highly selective, has a half-life of 3-4 h,...

Purpose:We set out to identify Stearoyl-CoA desaturase 1 (SCD1) as a novelmolecular target in clear cell renal cell carcinoma (ccRCC) and examine its role in tumor cell growth and viability in vitro and in vivo independently as well as in combination with current U.S. Food andDrug Administration (FDA)-approved

Fatty acid composition of adipose tissue associated with meat is an important factor for the beef industry because of its implications for human health, processing, meat quality, and palatability. Individual fatty acid composition is a trait under genetic control, so improvement via selective breeding of cattle is possible. The objective of this study was to investigate the genetic architecture...

Stearoyl CoA desaturase (SCD) is responsible for converting SFA into MUFA and plays an important role in regulating the fatty acid composition of tissues. Although the number of SCD isoforms differs among species, SCD-1 is the predominant isoform expressed in the major lipogenic tissues of all species studied. The SCD-1 gene promoter region has been cloned for several species, including the hum...

Abstract Brain metastases are a significant therapeutic challenge and associated with high morbidity mortality. Recent evidence suggests that brain have increased fatty acid synthesis compared to extracranial tumors. The enzyme stearoyl-CoA desaturase (SCD), which converts saturated long-chain acids into monounsaturated acids, is often upregulated in breast cancer metastasis (BCBM) considered p...

Gene expression profiles of bovine longissimus muscle as affected by dietary n-3 v. n-6 fatty acid (FA) intervention were analysed by microarray pre-screening of .3000 muscle biology/meat quality-related genes as well as subsequent quantitative RT-PCR gene expression validation of genes encoding lipogenesis-related transcription factors (CCAAT/enhancer-binding protein b, sterol regulatory eleme...