Objective(s):In this study, we aimed at evaluation of electrophysiological and histopathalogical characteristics of statin-induced muscle injury as well as clinical features of patients who develop this condition in terms of frequency and pattern of evolution. Materials and Methods: Forty patients (age 39-74 years) including 25 subjects with type 2 diabetes mellitus, 9 with cardiovascular disea...

Myopathy occurs in approximately 10% of statin-treated patients and is most commonly manifested by myalgias with or without plasma creatine kinase (CK) elevations. Predisposition exists in patients treated with high doses of potent statins and those who are older, female, have a genetic predisposition, and when statins are coadministered with drugs that compete with or inhibit drug metabolism. ...

Results of recent lipid lowering trials (Table 1) where new (dalcetrapib) and established agents (niacin) were tested on a background of statin therapy have been disappointingly negative. This outcome has been the cause of much consternation for those developing new lipid regulating drugs, and prompted reflection among experts on long-cherished concepts and the practical implications of continu...

The antifungal activities of amphotericin B/statin and nystatin/statin combinations against some opportunistic pathogenic fungi (Candida albicans, Candida glabrata, Paecilomyces variotii, Aspergillus fumigatus, Aspergillus flavus and Rhizopus oryzae) were investigated. The in vitro interactions between polyene antifungal drugs and different statins were evaluated using a standard chequerboard b...

Although statin drugs are generally efficacious for lowering plasma LDL-cholesterol levels, there is considerable variability in response. To identify candidate genes that may contribute to this variation, we used an unbiased genome-wide filter approach that was applied to 10,149 genes expressed in immortalized lymphoblastoid cell lines (LCLs) derived from 480 participants of the Cholesterol an...

The aim of the study was to investigate the association between statin use and open-angle glaucoma (OAG) risk in hyperlipidemia patients.We used the research database of the Taiwan National Health Insurance program to conduct a population-based case-control study. A total of 1276 patients with newly diagnosed OAG were identified from 2004 to 2011. Controls comprised of 12,760 patients without g...

BACKGROUND Accumulating evidence suggests that statins affect diseases other than cardiovascular disease, including cancer, and that these effects may depend on the lipid solubility of specific statins. Though many studies have reported an association between statin use and breast cancer incidence, the relationship between statin use and breast cancer recurrence has not been well studied. MET...

NEW DRUGS Fenofibric Acid (TriLipix) Plus a Statin for Cholesterol The FDA has approved Abbott’s feno fibric acid (TriLipix) delayed-release capsules along with diet to help lower triglyceride and low-density lipoproteincholesterol levels (LDL-C) and to raise high-density lipoprotein-cholesterol (HDL-C) levels. This is the first fibrate to be approved for use with a statin, although it has not ...

Statin monotherapy is generally well tolerated, with a low frequency of adverse events. The most important adverse effects associated with statins are myopathy and an asymptomatic increase in hepatic transaminases, both of which occur infrequently. Because statins are prescribed on a long-term basis, however, possible interactions with other drugs deserve particular attention, as many patients ...

BACKGROUND Cholesterol-lowering drugs known as statins have been reported to have significant anti-inflammatory properties. Given that inflammation may contribute to prostate cancer progression and that statins may reduce the risk for advanced prostate cancer, we investigated whether statin use was associated with reduced intratumoral inflammation in radical prostatectomy (RP) specimens. METH...