نتایج جستجو برای: stat4

تعداد نتایج: 718  

2014
Cinzia Ciccacci Carlo Perricone Fulvia Ceccarelli Sara Rufini Davide Di Fusco Cristiano Alessandri Francesca Romana Spinelli Enrica Cipriano Giuseppe Novelli Guido Valesini Paola Borgiani Fabrizio Conti

BACKGROUND Systemic lupus erythematosus (SLE) is an autoimmune disease with complex pathogenesis in which genes and environmental factors are involved. We aimed at analyzing previously identified loci associated with SLE or with other autoimmune and/or inflammatory disorders (STAT4, IL10, IL23R, IRAK1, PSORS1C1, HCP5, MIR146a, PTPN2, ERAP1, ATG16L1, IRGM) in a sample of Italian SLE patients in ...

Journal: :Human molecular genetics 2009
B Rueda J Broen C Simeon R Hesselstrand B Diaz H Suárez N Ortego-Centeno G Riemekasten V Fonollosa M C Vonk F H J van den Hoogen J Sanchez-Román M A Aguirre-Zamorano R García-Portales A Pros M T Camps M A Gonzalez-Gay M J H Coenen P Airo L Beretta R Scorza J van Laar M F Gonzalez-Escribano J L Nelson T R D J Radstake J Martin

The aim of this study was to investigate the possible role of STAT4 gene in the genetic predisposition to systemic sclerosis (SSc) susceptibility or clinical phenotype. A total of 1317 SSc patients [896 with limited cutaneous SSc (lcSSc) and 421 with diffuse cutaneous SSc (dcSSc)] and 3113 healthy controls, from an initial case-control set of Spanish Caucasian ancestry and five independent coho...

Journal: :International Journal of Biological Sciences 2007
Qiao Li Takekazu Iuchi Maria N. Jure-Kunkel Alfred E. Chang

Administration of anti-4-1BB mAb has been found to be a potent adjuvant when combined with other therapeutic approaches, e.g. chemotherapy, cytokine therapies, anti-OX40 therapy, and peptide or DC vaccines. However, the adjuvant effect of anti-4-1BB mAb administration in adoptive T cell therapy of cancer has not been fully evaluated. In this report, effector T cells were generated in vitro by a...

Journal: :Journal of immunology 2001
R Ortmann R Smeltz G Yap A Sher E M Shevach

B10.Q mice are normally susceptible to the induction of collagen-induced arthritis. We noted that one subline of B10.Q mice, B10.Q/J, was completely resistant to disease induction when immunized with collagen in CFA. B10.Q/J mice have a global defect in the generation of Th1 responses, and Ag-specific T cells derived from this strain failed to produce IFN-gamma. Because T cells from these mice ...

Journal: :Annals of the rheumatic diseases 2010
Elisabet Svenungsson Johanna Gustafsson Dag Leonard Johanna Sandling Iva Gunnarsson Gunnel Nordmark Andreas Jönsen Anders A Bengtsson Gunnar Sturfelt Solbritt Rantapää-Dahlqvist Kerstin Elvin Ulf Sundin Sophie Garnier Julia F Simard Snaevar Sigurdsson Leonid Padyukov Ann-Christine Syvänen Lars Rönnblom

OBJECTIVE To investigate whether the risk allele for systemic lupus erythematosus (SLE) in the signal transducer and activator of transcription factor 4 (STAT4) gene, defined by the single nucleotide polymorphism (SNP) rs10181656(G), is associated with vascular events and/or presence of prothrombotic anti-phospholipid antibodies (aPL) in patients with SLE. METHODS Two independent groups of un...

Journal: :Journal of immunology 2002
Alison Finnegan Michael J Grusby Charles D Kaplan Shannon K O'Neill Hermann Eibel Tamas Koreny Matyas Czipri Katalin Mikecz Jian Zhang

IL-4, a well-recognized modulator of macrophage activation, is perceived as an anti-inflammatory cytokine; however, under certain circumstances IL-4 may function as a proinflammatory cytokine. We have previously demonstrated that IL-4 treatment of mice with proteoglycan-induced arthritis (PGIA) inhibited the development of disease. To determine whether the capacity of IL-4 to inhibit disease is...

Journal: :Journal of immunology 2000
D Franchimont J Galon M Gadina R Visconti Y Zhou M Aringer D M Frucht G P Chrousos J J O'Shea

Glucocorticoids are widely used in the therapy of inflammatory, autoimmune, and allergic diseases. As the end-effectors of the hypothalamic-pituitary-adrenal axis, endogenous glucocorticoids also play an important role in suppressing innate and cellular immune responses. Previous studies have indicated that glucocorticoids inhibit Th1 and enhance Th2 cytokine secretion. IL-12 promotes Th1 cell-...

Journal: :Journal of immunology 2004
Po-Hui Chiang Lianfu Wang C Andrew Bonham Xiaoyan Liang John J Fung Lina Lu Shiguang Qian

The suppressive effect of rapamycin on T cells has been extensively studied, but its influence on the function of APC is less clear. The data in this study demonstrated that immunostimulatory activity of B10 (H2(b)) dendritic cells (DC) exposed to rapamycin (rapa-DC) was markedly suppressed as evidenced by the induction of low proliferative responses and specific CTL activity in allogeneic (C3H...

2001
Marina Afanasyeva Yan Wang Elizabeth A. Stafford Malte Dohmen Amir A. Sadighi Akha Noel R. Rose

Background—Interleukin (IL)-12 exerts a potent proinflammatory effect by stimulating T-helper (Th) 1 responses. This effect is believed to be mediated primarily through the activation of STAT4 and subsequent production of interferon (IFN). Methods and Results—We examined the role of IL-12 receptor (IL-12R) signaling in the development of murine experimental autoimmune myocarditis (EAM) induced ...

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