Increased destruction of red blood cells follows the insertion of ball valves into the heart in most cases. Usually, hemolysis is slight, but in some patients uncompensated hemolytic anemia develops. To study the influence on hemolysis of the mechanical properties of the prostheses, the degree of erythrocyte destruction was evaluated in patients with Starr-Edwards aortic prostheses of different...

Increased destruction of red blood cells follows the insertion of ball valves into the heart in most cases. Usually, hemolysis is slight, but in some patients uncompensated hemolytic anemia develops. To study the influence on hemolysis of the mechanical properties of the prostheses, the degree of erythrocyte destruction was evaluated in patients with Starr-Edwards aortic prostheses of different...

The Starr-Edwards model 6000 mitral valve was the first successful mitral prosthesis. A fifteen year follow-up of 110 patients undergoing isolated mitral valve replacement with this prosthesis from 1960 to 1966 is presented. There were 22 (20%) operative and 37 (42%) late deaths at a mean of 8.6 years postoperatively. Preoperative variables leading to late death and thromboembolism are analyzed...

1. The haemolytic complications of Starr-Edwards ball and cage prostheses have been studied in ninety-five patients. 2. Intravascular haemolysis has been found to be common and particularly marked after an aortic valve replacement. 3. A simple and reliable method for estimating urinary iron is described, and excessive urinary iron loss was found to be common especially in aortic valve replaceme...