INTRODUCTION The objective of this study is to assess whether the results of loop ileostomy closure in terms of morbidity and hospital stay are influenced by the type of anastomosis and suture used. METHOD All patients who underwent loop ileostomy closure were reviewed. A retrospective cohort study comparing morbidity and hospital stay according to the type of anastomosis (TT/LL) and the type...

As key negative regulator of the p53 tumour suppressor, Mdm2 is an attractive therapeutic target. Small molecules such as Nutlin have been developed to antagonise Mdm2, resulting in p53-dependent death of tumour cells. We have recently described a mutation in Mdm2 (M62A), which precludes binding of Nutlin, but not p53. This Nutlin-resistant variant is not, however, refractory to binding and inh...

INTRODUCTION Anastomotic leak is one of the main causes of morbidity following esophageal resection for carcinoma of the esophagus and gastroesophageal junction. We compared hand sewn and stapled cervical esophagogastric anastomotic techniques in terms of postoperative complications. METHODS All patients who underwent esophagectomy with cervical esophagogastric anastomosis at a single academi...

Previous publications on stapled peptide inhibitors against Mdm2/Mdm4-p53 interactions have established that this new class of drugs have the potential to be easily optimised to attain high binding affinity and specificity, but the mechanisms controlling their cellular uptake and target engagement remain elusive and controversial. To aid in understanding the rules of peptide and staple design, ...

Aim: To compare the clinical long term complication of Stapled Hemorrhoidectomy versus Open Hemorrhoidectomy in term of Recurrence and Anal Stenosis. Place and duration of study: Department of Surgery at Shalamar Hospital Lahore from March 2014 to February 2015. Methods: Randomized Control Trial at Surgical Unit II, Shalamar Hospital Lahore. Results: Out of total 50 patients there were 20(80%) ...

BACKGROUND Hand-sewn gastrointestinal anastomoses has been the traditional approach to gastrointestinal anastomosis in Nigeria while stapled anastomoses are infrequently performed in few centers. OBJECTIVES To describe the outcome of our initial experience with stapled gastrointestinal anastomoses in a semi-urban patient population. PATIENTS AND METHODS Consecutive patients who had stapled ...

A stapled sequence is a set of consecutive positive integers such that no one of them is relatively prime with all of the others. The problem of existence and construction of stapled sequences of length N was extensively studied for over 60 years by Pillai, Evans, Brauer, Harborth, Erdös and others. Sivasankaranarayana, Szekeres and Pillai proved that no stapled sequences exist for any N < 17. ...