With the rapid growth of streaming media applications, there has been a strong demand of Quality-of-Experience (QoE) measurement and QoE-driven video delivery technologies. While the new worldwide standard dynamic adaptive streaming over hypertext transfer protocol (DASH) provides an inter-operable solution to overcome the volatile network conditions, its complex characteristic brings new chall...

The 3D structures of all 12 mispairs formed in the active site of a DNA polymerase help explain their differential effects on polymerase stalling and on translocation of the primer terminus to the enzyme's proofreading site.

A quantitative comparison of the BSP and LogP models of parallel computation is developed. We concentrate on a variant of LogP that disallows the so-called stalling behavior, although issues surrounding the stalling phenomenon are also explored. Very eecient cross simulations between the two models are derived, showing their substantial equivalence for algorithmic design guided by asymptotic an...

Translation of consecutive prolines causes ribosome stalling, which is alleviated but cannot be fully compensated by the elongation factor P. However, the presence of polyproline motifs in about one third of the E. coli proteins underlines their potential functional importance, which remains largely unexplored. We conducted an evolutionary analysis of polyproline motifs in the proteomes of 43 E...

Accurate DNA replication is essential for genomic stability. One mechanism by which high-fidelity DNA polymerases maintain replication accuracy involves stalling of the polymerase in response to covalent incorporation of mismatched base pairs, thereby favoring subsequent mismatch excision. Some polymerases retain a "short-term memory" of replication errors, responding to mismatches up to four b...