Developing drugs for cancer is a process as complex the disease itself. At planning stage of clinical trial an oncology drug, thorough and careful consideration must be given to choosing right study design endpoints/estimands, any bias introduced at outset would cascade down analysis eventually reporting results. The common designs drugs, their challenges, current perspectives (and dilemmas) in...

A phase separation process model formed by the Cahn-Hilliard equation and the heat equation is considered. The mobility coefficient in the Cahn-Hilliard equation is assumed to be an increasing function of the temperature. This property is of importance at the latest stage of the cooling process. The existence and uniqueness of a weak solution is proved, and a uniform cooling problem is studied....

A concise approach is proposed to determine a reduced order control design oriented dynamical model of multi-stage hot sheet metal forming process starting from high-dimensional coupled thermo-mechanical model. The obtained nonlinear parametric serves as basis for the an Extended Kalman filter estimate spatial-temporal temperature distribution in blank during based on sparse local measurements....

The development of multistep nucleation theory has spurred on experimentalists to find intermediate metastable states that are relevant to the solidification pathway of the molecule under interest. A great deal of studies focused on characterizing the so-called "precritical clusters" that may arise in the precipitation process. However, in macromolecular systems, the role that these clusters mi...

LEG carriers’ energy efficiency can be increased by improving the boil-off gas (BOG) reliquefaction installation processes in its components. In this study, it is proposed to replace conventional process (CRP) of a carrier “ANTIKITIRA” actual equipped throttle devices with an ejector (ERP) having two-phase ejectors as expansion increase installation. Expansion EV2E and EV2R were replaced system...

Heart rate variability is assumed to result from a multiplicative or cascade mechanism based on its multifractal property. Numerical results on the perturbation of the cascade are given to compare HRV under parasympathetic (PNS) and sympathetic (SNS) autonomic blockades. It was found that qualitative change of the HRV multifractal, which was observed in PNS blockade, is due to the change from a...

Carbon fibers are widely used in many industrial applications due the fact of their excellent properties. Carbonaceous mesophases are liquid crystalline precursor materials that can be spun into high performance carbon fibers using the melt spinning process, which is a flow cascade consisting of pressure driven flow-converging die flow-free surface extensional spinline flow that modifies the pr...

Cascades represent an important phenomenon across various disciplines such as sociology, economy, psychology, political science, marketing, and epidemiology. An important property of cascades is their morphology, which encompasses the structure, shape, and size. However, cascade morphology has not been rigorously characterized and modeled in prior literature. In this paper, we propose a Multi-o...

Fresh juices of colourful wild berries: cornelian cherry, blackthorn, white beam and elderberry are considered as valuable, highly nutritive beverages and characterized by the high level of vitamins and antioxidant capacity. The concentration process of these juices by membrane osmotic distillation was studied, where only water vapour is eliminated, while the heat sensitive, valuable compounds ...