BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is a major risk factor for hepatocellular carcinoma (HCC). However, the mechanistic pathways that link both disorders are essentially unknown. OBJECTIVE Our study was designed to investigate the role of microRNA-21 in the pathogenesis of NAFLD and its potential involvement in HCC. METHODS Wildtype mice maintained on a high fat diet (HFD) ...

Lipogenesis must be regulated tightly to meet metabolic needs according to nutritional status. During fasting, fatty acid synthesis is virtually absent mainly due to increased glucagon/cAMP signaling [1]. In contrast, during feeding, fatty acid synthesis mainly in liver increases drastically, especially when the diet is carbohydrate rich, as glucose utilization and glycolysis increase [2]. Incr...

Nuclear hormone receptors liver X receptor (LXRa and LXRb) ligands are attractive approaches for the treatment of dyslipidemia and atherosclerosis. To further elucidate the function of LXRa in liver lipid metabolism in a disease-relevant animal model, the KKAy mouse, we used adenoviral vectors to selectively knock down LXRa gene expression. Out of five different short hairpin RNAs (shRNAs) that...

The present study investigates the effects of dietary protein levels on glucolipid metabolism, immune function, and resistance to Streptococcus agalactiae genetically improved farmed tilapia (GIFT) exposed high temperature. Six practical diets were prepared feed 360 fish (initial weight 43.78 ± 0.12 g) with graded (26.45%, 29.28%, 31.69%, 33.68%, 36.18%, 38.75% dry matter). results showed that ...