5-Hydroxytryptamine 2A (5-HT2A) receptors, a major site of action of clozapine and other atypical antipsychotic medications, are, paradoxically, internalized in vitro and in vivo by antagonists and agonists. The mechanisms responsible for this paradoxical regulation of 5-HT2A receptors are unknown. In this study, the arrestin and dynamin dependences of agonist- and antagonist-mediated internali...

Spheroid formation is one property of stem cells-such as embryo-derived or neural stem cells-that has been used for the enrichment of cancer stem-like cells (CSLCs). However, it is unclear whether CSLC-derived spheroids are heterogeneous or whether they share common embryonic stemness properties. Understanding these features might lead to novel therapeutic approaches. Ovarian carcinoma is a dea...

Abstract At fertilization in mice and humans, the activation of egg is caused by a series repetitive Ca2+ oscillations which are initiated phospholipase-C(zeta)ζ that generates inositol-1,4,5-trisphophate (InsP3). can be triggered mature mouse eggs incubation Sr2+ containing medium, but this does not appear to effective human eggs. Here, we have investigated reason for apparent difference using...

Radioactive wastewater contaminated with 137Cs and 90Sr are produced at different stages of the nuclear fuel cycle. Transferring these radionuclides to a stable solid matrix is crucial for safe management long-term storage. Sitinakite Crystalline silicotitanates (CSTs) among most selective mineral ion exchangers Cs and/or Sr depending on pH medium CST chemical composition (Nb doping). To better...

We present results from two-photon photoassociative spectroscopy of the least-bound vibrational level of the X 1 g + state of the Sr2 dimer. Measurement of the binding energy allows us to determine the s-wave scattering length a88=−1.4 6 a0. For the intermediate state, we use a bound level on the metastable S0P1 potential, which provides large Franck-Condon transition factors and narrow one-pho...

Karst groundwater is the most important source of water supply for Shanxi province, northern China. In this study, different hydrogeochemical indices along with multiple isotope (2H, 18O, and 87Sr/86Sr) were used to identify main factors controlling salinization processes in Xin’an karst system at Shanxi. The region’s was divided into three geologically distinct subsystems, namely, Changzhi–Xia...

Development of high performance electrocatalysts for oxygen evolution reaction (OER) in acidic media remains a challenge direct water splitting using an electrolyzer. Recently, Ruddlesden-Popper phase Sr2IrO4 was discovered to be efficient OER catalyst because its unique structure, which consists layers both rock salt and perovskite phases simultaneously. In this study, we prepared series B-sit...