The blood-testis barrier (BTB) prevents the entry of many drugs into seminiferous tubules, which can be beneficial for therapy not intended for the testis but may decrease drug efficacy for medications requiring entry to the testis. Previous data have shown that some of the transporters in the multidrug resistance-associated protein (MRP) family (ABCC) are expressed in the testis. By determinin...

We invent a new science which is better than physics. It is even better than chocolate. It is not illegal, immoral, or fattening. However, thinking about it too hard does tend to give you a headache. On the other hand, thinking about it even harder makes your brain numb. <-------------------------------------150mm--------------------------------------> WARNING: Do not read this paper before ope...

Nicotine is an addictive alkaloid in cigarette smoke and is responsible for tobacco dependence. It is important to consider the bloodto-liver transport of nicotine to understand the nicotine elimination from the body because most of the nicotine is converted to inactive metabolites by cytochrome P450 localized in the endoplasmic reticulum of the hepatocytes. In this study, the blood-to-liver tr...

Nicotine is an addictive alkaloid in cigarette smoke and is responsible for tobacco dependence. It is important to consider the bloodto-liver transport of nicotine to understand the nicotine elimination from the body because most of the nicotine is converted to inactive metabolites by cytochrome P450 localized in the endoplasmic reticulum of the hepatocytes. In this study, the blood-to-liver tr...