Extramammary Paget’s disease and vulvar intraepithelial neoplasia are common lesions of vulve, but synchronous occurrence is rare in a same location. Herein we describe a concurrence of primary cutaneous extra mammary Paget’s disease and squamous cell carcinoma in situ of vulva in an Iranian women. A 59 year old woman, initially presented to Kosar teaching hospital gynecology clinic April 2017 ...

Since the first associations between human papilloma-virus (HPV)-16 and cervical squamous neoplasia 25 years ago, the field of cervical cancer prevention and precursor diagnosis has continued to evolve, culminating recently with the validation of vaccines that promise to significantly reduce the incidence of this disease. The significance of HPV-16 was appreciated early by its strong associatio...

MATERIAL AND METHODS The current study analyzed the degree of agreement between HPV testing, Pap smear, and colposcopic directed cervical biopsies. The study was performed on a group of 332 patients diagnosed and treated for cervical dysplasia at Cuza-Vodă Obstetrics-Gynecology Clinic Hospital and Suceava County Hospital between 2006 and 2011. RESULTS 190 patients (57.23%) were positive for H...

Four antibodies (anti-CCA, anti-CEA, Ca-l, and anti-EMA) were used to study the distribution of antibody-binding sites in normal endocervical mucosa, metaplastic squamous epithelium, squamous epithelium exhibiting varying grades of intraepithelial neoplasia, and invasive squamous cell carcinoma. Anti-CCA, a novel monoclonal antibody raised against an extract of squamous cell carcinoma of the ce...

LS: lichen sclerosus PeIN: penile intraepithelial neoplasia L ichen sclerosus (LS) is a chronic disorder with a predilection for the anogenital area. In this anatomic area, a subset of human papillomavirusenegative neoplasms arise on the background of chronic inflammation, of which LS is the most common condition. Of these neoplastic associations, squamous intraepithelial neoplasias, including ...

A woman presenting with vulval lesions is to be examined and evaluated further before giving her the definitive diagnosis proposing treatment. As differential may vary from benign like lichen sclerosus, intraepithelial neoplasia or malignant squamous cell carcinoma. We are a case report wherein 70 year presented features similar carcinoma but was diagnosed as pseudoepitheliomatous hyperplasia o...

Erratum The original version of this article [1] unfortunately contained incorrect figure files. Figures 4 and 7 in main body which have been replaced with new version of these figures. The corrected Figures include 3 added HE (a,b,c) and total 15 (a-o) figures, each. The new version of these files are included below. Furthermore, Additional File 1 has been updated to remove Fig. 3 and 6 which ...

No standard screening programs exist to detect vulvar carcinoma or its precursor lesions, and therefore gynecologists, dermatologists and other healthcare providers in this field should be aware of the clinical features, behavior and management of the different existing premalignant vulvar lesions, squamous vulvar intraepithelial neoplasia (VIN), vulvar Paget's disease and melanoma in situ. In ...

OBJECTIVES The aims of this study were to assess the number of cases diagnosed as glandular neoplasia (national report code 6) of cervical (6A) and non-cervical (6B) types on ThinPrep (TP) and SurePath (SP) liquid-based cytology (LBC) samples and to calculate the positive predictive value (PPV) of these diagnoses for significant glandular and/or squamous pathology for local audit and as a contr...