Plant isoprenoids represent a large group of compounds with a wide range of physiological functions. In the cytosol, isoprenoids are synthesized via the classical acetate/mevalonate pathway. In this pathway, farnesyl diphosphate (FPP) occupies a central position, from which isoprene units are dispatched to the different classes of isoprenoids, with sterols as the major end products. The present...

This paper describes a systematic methodology (Conceptual Framework) to derive quality standards for organic (anthropogenic) contaminants in sewage sludge added to agricultural land, in the context of revision of EU Sludge Directive 86/278/EEC and the broader Soil Thematic Strategy. The overall objective is to ensure, based on a risk assessment approach, a sustainable use of sludge over a long ...

Wireless sensor networks operate in unattended and untethered mode where power consumption is of greatest importance. General purpose adaptive infrastructures are useful for dissemination of user interests and collection of sensor data. We present a sensor querying mechanism (SQS) which provides local query optimization and in-network message concatenation for energy efficient response delivery...

The impact of metabolic engineering on nontarget pathways and outcomes of metabolic engineering from different genomes are poorly understood questions. Therefore, squalene biosynthesis genes FARNESYL DIPHOSPHATE SYNTHASE (FPS) and SQUALENE SYNTHASE (SQS) were engineered via the Nicotiana tabacum chloroplast (C), nuclear (N) or both (CN) genomes to promote squalene biosynthesis. SQS levels were ...

A number of new functionalities have been added to the Alloy Theoretic Automated Toolkit (ATAT) since it was last reviewed in this journal in 2002. ATAT can now handle multicomponent multisublattice alloy systems, nonconfigurational sources of entropy (e.g. vibrational and electronic entropy), Special Quasirandom Structures (SQS) generation, tensorial cluster expansion construction and includes...

The gravity-mode (g-mode) eigenfrequencies of newly born strange quark stars (SQSs) and neutron stars (NSs) are studied. It is found that the eigenfrequencies in SQSs are much lower than those in NSs by almost 1 order of magnitude, since the components of a SQS are all extremely relativistic particles while nucleons in a NS are nonrelativistic. We therefore propose that newly born SQSs can be d...

Topological (2D) Fuzzy Pharmacophore Triplets (2DFPT), using the number of interposed bonds to measure separation between the atoms representing pharmacophore types, were employed to establish and validate Quantitative Structure-Activity Relationships (QSAR). Thirteen data sets for which state-of-the-art QSAR models were reported in literature were revisited in order to benchmark 2D-FPT biologi...

Mesquita, J.O.1#, Machado, A.R.1# Del Sarto, R.P.1, Martins, A.M.A2* 1UDF – Centro Universitário do Distrito Federal, Brazil 2Liver Transplantation Center, HUWC / Federal University of Ceara UFC, Brazil / Brazilian Center for Protein Research, Department of Cell Biology, University of Brasilia, UNB – DF, Brazil #these authors contributed equally to this work. *Corresponding author: Dr. Aline M ...

The observations of compact star inspirals from LIGO/Virgo provide a valuable tool to study the highly uncertain equation state (EOS) dense matter at densities in which stars reside. It is not clear whether merging are neutron or quark containing self-bound matter. In this work, we explore allowed bag-model-like EOSs by assuming strange (SQSs) Bayesian analysis employing tidal deformability obs...