antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs, chloroquine (cq) and amodiaquine (aq), have been used to prevent and treat malaria for many years. the importance of these drugs is related to their simple usage, high efficacy, affordability, and cost-effectiveness of their synthesis. in recent years, with the spread of parasite resistance to cq and cross-resist...

multidrug resistant (mdr) bacteria are spread through the world which causes nosocomial infections, especially in intensive care unit (icu). this study aimed to investigate resistance pattern of pseudomonas aeruginosa and enterobacter cloacae isolated from patients in icu. during 2011-2012, 30 isolates for each p. aeruginosa and e. cloacae were collected from patients who acquired nosocomial in...

Significant increases in the prevalence of resistance to antibiotics have been observed in common pathogen of humans worldwide. The consequences of the appearance and spread of antimicrobial resistance have included increasing morbidity, mortality, and cost of health care. The increasing use of antimicrobial agents promotes the appearance and spread of bacterial resistance. Strict clinical guid...

Abstract Background Growth of drug resistance is related to number of microbial characteristics, selective pressure by antibiotic use and social and technical vicissitudes that enhance the transmission of antibiotic resistant organisms. The aim of this study was to investigate antimicrobial-resistance of Escherichia coli isolated from children in Shahid Sadoughi hospital of Yazd. Material...

b ackground: methicillin-resistant staphylococcus aureus (mrsa) is the one of most commonly isolated organisms from clinical samples which can cause life- threatening infections. the emergence and spread of antibiotic resistance makes the treatment of these infections more complicated. in this study, we aimed to determine  the  patterns  of  antibiotic  resistance  among  mrsa  isolates  from t...

Introduction: This study aimed to determine the frequency of extended-spectrum beta-lactamases (ESBL) and different drug resistance phenotypes in Enterobacteriaceae isolated from clinical specimens in Gonbad-e Kavus, Golestan Province. Methods: 220 clinical samples of urine, blood, pus, sputum, CSF, body fluids, and ear and eye discharge were collected during six months from April to September ...