Surface plasmon resonance (SPR) imaging sensors realize label free, real-time, highly sensitive, quantitative, high throughput biological interaction monitoring and the binding profiles from multi-analytes further provide the binding kinetic parameters between different bio-molecules. In the past two decades, SPR imaging sensors found rapid increasing applications in fundamental biological stud...

In this report, gold nanorods (GNRs) were used to enhance the sensitivity of the wavelength-modulated surface plasmon resonance (SPR) biosensor. The GNRs were designed and fabricated through seed-medicated growth and surface activation by a layer of a weak polyelectrolyte, poly(acrylic acid) for the attaching antibody. Rabbit anti-goat IgG was immobilized on GNRs, and sandwich assays were carri...

In this work, we explore the sensing applications of Surface Plasmon Resonance (SPR) enhanced transmission of light through 1-D metal gratings on commonly available compact discs (CDs). We show that SPR on CDs (CD-SPR) can be used to build a simple and compact angular displacement measurement system with submicro-radian resolution. In addition we show that by controlling the azimuthal angle of ...

Psycholinguistic and cognitive psychology studies involving self-paced reading (SPR) paradigm are usually carried out in conventional laboratory settings. This is mainly due to the need for accurate response time measurements in such experiments. This project explores the potentials and limitations of web-based SPR experiments. The existing timing component of WebExp2, an experiment generator, ...

We study the effect of photodiode angular response on the measurement of surface plasmon resonance (SPR) in metallic thin films using the Kretschmann-Raether configuration. The photodiode signal depends not only on the light intensity but also on the incidence angle. This implies that the photodiode sensitivity changes along the SPR curve. Consequently, the measured SPR spectrum is distorted, t...

The performance of chemical reactions has been enhanced immensely with surface plasmon resonance (SPR)-based sensors. In this review, the principle and application of SPR sensors are introduced and summarized thoroughly. We introduce the mechanism of the SPR sensors and present a thorough summary about the optical design, including the substrate and excitation modes of the surface plasmons. Add...

Surface plasmon resonance (SPR) technique offers a robust label-free approach applicable in various investigations including binding affinity, specificity and kinetics of biological macromolecules (e.g., peptides, proteins and nucleotidase) and small molecules. SPR provides extremely important data on the kinetics and affinity of substances examined, through which bio-specific interaction(s) ca...

In this paper, the authors present a linear matrix inequality (LMI) approach to the strictly positive real (SPR) synthesis problem: find an output feedback K such that the closed-loop system T (s) is SPR. The authors establish that if no such constant output feedback K exists, then no dynamic output feedback with a proper transfer matrix exists to make the closed-loop system SPR. The existence ...

The combined use of surface plasmon resonance (SPR) and modified or mimic oligonucleotides have expanded diagnostic capabilities of SPR-based biosensors and have allowed detailed studies of molecular recognition processes. This review summarizes the most significant advances made in this area over the past 15 years.   Functional and conformationally restricted DNA analogs (e.g., aptamers an...

Polarization-contrast microscopy coupled with an atomic force microscope is utilized to attain far-field optical images of the multipolar surface plasmon resonance (SPR) modes of single gold nano-rod. Modulated standing modes resulted from the interference of longitudinal SPR modes and incident light are observed and studied. By counting the average distance of adjacent beats on this single gol...